2025/03/27 更新

写真a

イケダ シュンタロウ
池田 俊太郎
Ikeda Shuntaro
所属
大学院医学系研究科 医学専攻 教授
職名
教授
連絡先
メールアドレス
外部リンク

学位

  • 医学博士 ( 愛媛大学 )

所属学協会

▼全件表示

論文

  • Safety and Efficacy of Imeglimin for Type 2 Diabetes Mellitus in Patients With Heart Failure. 国際誌

    Tomoaki Nishikawa, Akinori Higaki, Keisho Kurokawa, Kohei Yoshimoto, Rikako Horie, Yasuhisa Nakao, Tomoki Fujisawa, Shigehiro Miyazaki, Yusuke Akazawa, Toru Miyoshi, Hiroshi Kawakami, Haruhiko Higashi, Shunsuke Tamaki, Kazuhisa Nishimura, Katsuji Inoue, Shuntaro Ikeda, Osamu Yamaguchi

    In vivo (Athens, Greece)   39 ( 1 )   375 - 380   2025年

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    BACKGROUND/AIM: Imeglimin, a novel oral antidiabetic agent, was approved in 2021 for the treatment of type 2 diabetes mellitus (T2DM). Phase III clinical trials demonstrated its safety and efficacy in managing T2DM. However, its safety profile in patients with heart failure has not been thoroughly evaluated in real-world clinical settings. PATIENTS AND METHODS: We analyzed cases of patients with heart failure (stage B or higher) who were newly prescribed imeglimin, based on electronic medical records from June 2022 to June 2024. Baseline clinical data at the initiation of imeglimin therapy were collected, and cardiovascular events, adverse effects (e.g., lactic acidosis), and blood test results, including glycated hemoglobin A1c (HbA1c), were assessed as of July 2024. RESULTS: A total of 21 patients met the inclusion criteria. HbA1c levels significantly decreased after an average of 312.1±205.8 days of imeglimin therapy (baseline vs. on therapy: 8.2±1.0% vs. 7.5±0.7%, p=0.001). Alanine aminotransferase levels were also significantly reduced (baseline vs. on therapy: 30.9±23.8 IU/l vs. 22.0±12.3 IU/l, p=0.022). No adverse drug reactions were observed during the treatment period. Major adverse cardiovascular events occurred in three patients (14%), although a clear association with imeglimin remains uncertain. CONCLUSION: Imeglimin demonstrated safety and efficacy in T2DM in patients with coexisting heart failure.

    DOI: 10.21873/invivo.13838

    PubMed

    researchmap

  • Excessive supraventricular ectopic activity is a simple cutoff for predicting late recurrence of atrial fibrillation after ablation.

    Tomoki Fujisawa, Hiroshi Kawakami, Shunsuke Tamaki, Shigehiro Miyazaki, Yusuke Akazawa, Toru Miyoshi, Akinori Higaki, Fumiyasu Seike, Haruhiko Higashi, Kazuhisa Nishimura, Katsuji Inoue, Shuntaro Ikeda, Osamu Yamaguchi

    Heart and vessels   2024年12月

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    The relationship between post-ablation excessive supraventricular ectopic activity (ESVEA), a new marker for new-onset atrial fibrillation (AF), and late AF recurrence is uncertain. We enrolled 469 patients with AF who underwent initial radiofrequency catheter ablation and 24-h Holter monitoring the day after. Early AF recurrence (n = 57; 12%) and ESVEA (n = 242; 52%) were noted. During a median follow-up of 25 months, 152 (32%) patients experienced late AF recurrence. Patients with early AF recurrence or ESVEA were significantly more likely to experience late recurrence (p = 0.02). Even without AF, ESVEA was associated with late recurrence following AF ablation.

    DOI: 10.1007/s00380-024-02498-z

    PubMed

    researchmap

  • Severe restenosis after stentless treatment with coronary intravascular lithotripsy for calcified nodule lesions: a serial observation with IVUS. 国際誌

    Rina Konishi, Akinori Higaki, Toru Miyoshi, Kazuhisa Nishimura, Shuntaro Ikeda, Osamu Yamaguchi

    Oxford medical case reports   2024 ( 12 )   omae156   2024年12月

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    An 82-year-old woman with a history of myocardial infarction presented with worsening effort angina. Coronary angiography (CAG) revealed 75% stenosis in the proximal left anterior descending artery (LAD), with intravascular ultrasound (IVUS) identifying a severe calcified nodule near a previously implanted drug-eluting stent. The lesion was treated with intravascular lithotripsy (IVL) and a drug-coated balloon (DCB), avoiding left main crossover stenting. Despite initial success, the patient experienced restenosis three months later, managed conservatively based on favorable DFR/FFR values. However, worsening symptoms led to repeat CAG, revealing 99% restenosis with calcified nodule. A second IVL was performed, followed by crossover stenting from the left main to the LAD, achieving successful stent expansion. This case underscores the potential for severe restenosis following IVL and DCB angioplasty, highlighting the limitations of IVL in reducing calcified plaque volume and the importance of close follow-up.

    DOI: 10.1093/omcr/omae156

    PubMed

    researchmap

  • Remote dielectric sensing predicts elevated left atrial pressure in patients with atrial fibrillation. 国際誌

    Shunsuke Tamaki, Katsuji Inoue, Hiroshi Kawakami, Tomoki Fujisawa, Ryo Miyabe, Yasuhisa Nakao, Shigehiro Miyazaki, Yusuke Akazawa, Toru Miyoshi, Akinori Higaki, Fumiyasu Seike, Haruhiko Higashi, Kazuhisa Nishimura, Shuntaro Ikeda, Osamu Yamaguchi

    International journal of cardiology. Heart & vasculature   53   101459 - 101459   2024年8月

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    BACKGROUND: There are currently no established non-invasive indices of echocardiography for elevated left atrial pressure (LAP) especially in patients with atrial fibrillation (AF). Remote dielectric sensing (ReDS) is a novel non-invasive electromagnetic energy-based technology that quantifies total lung fluid, enabling the monitoring of volume status in patients with heart failure. The utility of ReDS for estimating LAP in patients with AF remains unknown. METHODS: We prospectively investigated patients with AF in whom LAP was directly measured during catheter ablation for AF, and ReDS measurements were conducted the day before ablation. Elevated LAP was defined as LAP ≥ 15 mmHg. RESULTS: A total of 61 patients were included (median age 66 years, 38 % female). Among them, 26 patients had elevated LAP. There was a positive correlation between ReDS and LAP (r = 0.363, P = 0.004). Receiver operating characteristic curve analysis for the prediction of elevated LAP demonstrated that the best cut-off value of ReDS was 30 %, with a sensitivity of 65 %, specificity of 69 %, and an area under the curve of 0.703 (95 % confidence interval 0.568-0.837). Multivariate logistic regression analysis revealed that ReDS was an independent predictor of elevated LAP, among covariates including left ventricular ejection fraction, the ratio of early transmitral flow velocity to septal mitral annular early diastolic velocity, and left atrial volume index. CONCLUSIONS: Our results suggest ReDS could be a valuable marker of elevated LAP even in patients with AF. Further studies are needed to elucidate the effectiveness of a ReDS-guided decongestive strategy in patients with heart failure.

    DOI: 10.1016/j.ijcha.2024.101459

    PubMed

    researchmap

  • Impact of Aromatase Inhibitors Treatment Duration on Coronary Artery Calcification in Postoperative Patients With Breast Cancer. 国際誌

    Yu Hiasa, Akinori Higaki, Yoshiaki Kamei, Tomoaki Nishikawa, Ryo Miyabe, Tomoki Fujisawa, Shigehiro Miyazaki, Yusuke Akazawa, Toru Miyoshi, Hiroshi Kawakami, Fumiyasu Seike, Haruhiko Higashi, Shunsuke Tamaki, Kazuhisa Nishimura, Katsuji Inoue, Shuntaro Ikeda, Osamu Yamaguchi

    The Canadian journal of cardiology   2024年7月

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    BACKGROUND: Aromatase inhibitors (AIs) are the standard therapeutic approach for hormone receptor-positive postmenopausal breast cancer. However, there are concerns about increased cardiovascular risk due to their antioestrogenic effects. This study aimed to investigate the potential association between duration of AI treatment and the severity of coronary artery calcification (CAC). METHODS: The study included outpatients who initiated adjuvant endocrine therapy with AIs for breast cancer from August 2010 to October 2022. CAC was quantified according to a visual ordinal scoring system. Patient characteristics were assessed based on the presence of CAC. Independent risk factors for elevated CAC scores were identified through a multivariable logistic regression model. RESULTS: Among 357 patients, 44.8% exhibited CAC. No significant difference in AI treatment duration was observed between groups (1268 d [interquartile range (IQR) 725-1743 d] vs 1104 d [IQR 685-1683.25 d]; P = 0.236). Patients with CAC were characterised by higher age (63.06 y [56.81-68.78 y] vs 74.39 y [68.98-80.03 y]; P < 0.001), lower hemoglobin levels (g/dL: 13.20L [IQR 12.60-13.70L] vs 12.60 [IQR 11.60-13.43]; P < 0.001), and reduced estimated glomerular filtration rate (mL/min/1.73 m2: 72.00 [IQR 61.80-81.50] vs 62.80 [IQR 51.27-71.90]; P < 0.001) compared with those without CAC. The prevalences of hypertension, diabetes mellitus, and dyslipidemia were significantly higher in patients with CAC. No correlation was found between the duration of AI treatment and CAC score (R = -0.02; P = 0.78). Independent risk factors for CAC included higher age, lower hemoglobin levels, and the presence of hypertension and diabetes mellitus in postoperative patients with breast cancer. CONCLUSIONS: The duration of AI treatment does not exert a significant influence on CAC in postoperative patients with breast cancer.

    DOI: 10.1016/j.cjca.2024.05.012

    PubMed

    researchmap

▼全件表示

MISC

  • 一般的心血管疾患の心うっ血に対する生体電気インピーダンス解析誘導細胞外容積状態の予測能

    宮崎慈大, 檜垣彰典, 日浅悠, 神山雅喜, 宮部亮, 中尾恭久, 藤澤友輝, 赤澤祐介, 三好徹, 川上大志, 清家史靖, 東晴彦, 玉置俊介, 西村和久, 井上勝次, 池田俊太郎, 山口修

    日本循環器学会学術集会(Web)   88th   2024年

     詳細を見る

  • 左房リザーバー機能評価は心アミロイドーシスと肥大型心筋症の鑑別に有用である

    東晴彦, 井上勝次, 木下将城, 藤井昭, 上谷晃由, 青野潤, 永井啓行, 西村和久, 池田俊太郎, 山口修

    超音波医学   46 ( Supplement (CD-ROM) )   S591(J‐STAGE)   2019年4月

     詳細を見る

    記述言語:日本語  

    J-GLOBAL

    researchmap

  • Clinical Significance of Atrial Electromechanical Conduction Time during Long-term Follow-up in Patients after Catheter Ablation for Atrial Fibrillation(和訳中)

    藤井 昭, 井上 勝次, 永井 啓行, 木下 将城, 佐々木 康浩, 赤澤 祐介, 東 晴彦, 上谷 晃由, 青野 潤, 西村 和久, 池田 俊太郎, 山口 修

    日本循環器学会学術集会抄録集   83回   PJ021 - 6   2019年3月

     詳細を見る

    記述言語:英語   出版者・発行元:(一社)日本循環器学会  

    researchmap

  • Evaluation of Plaque Characteristics with Multi-detector Row Computed Tomography Based on Diluted Contrast-injection Protocol Compared with Integrated Backscatter Intravascular Ultrasound(和訳中)

    中尾 恭久, 上谷 晃由, 赤澤 祐介, 清家 史靖, 東 晴彦, 藤井 昭, 青野 潤, 永井 啓行, 西村 和久, 吉田 和樹, 田邉 裕貴, 城戸 輝仁, 倉田 聖, 望月 輝一, 池田 俊太郎, 山口 修

    日本循環器学会学術集会抄録集   83回   PJ020 - 1   2019年3月

     詳細を見る

    記述言語:英語   出版者・発行元:(一社)日本循環器学会  

    researchmap

  • FFRの測定時間がpressure driftに与える影響

    浅木 康志, 上谷 晃由, 西村 和久, 石原 隆史, 山田 文哉, 池田 俊太郎, 山口 修

    日本循環器学会学術集会抄録集   83回   CP04 - 2   2019年3月

     詳細を見る

    記述言語:日本語   出版者・発行元:(一社)日本循環器学会  

    researchmap

▼全件表示