2025/03/27 更新

写真a

ユカワ　マサシ
湯川　将之
Yukawa Masashi
所属
医農融合公衆衛生学環 講師
職名
講師
連絡先
メールアドレス
外部リンク

学位

  • 博士（生命科学） （ 2013年6月   東京大学 ）

  • 修士（生命科学） （ 2008年3月   東京大学 ）

研究キーワード

  • 細胞外DNA

  • クロマチン

  • エピゲノム

  • ヘルパーT細胞

  • 次世代シーケンシング

  • バイオインフォマティクス

研究分野

  • ライフサイエンス / 医用システム

  • ライフサイエンス / 細胞生物学

  • ライフサイエンス / システムゲノム科学

  • ライフサイエンス / 免疫学

学歴

  • 東京大学   大学院新領域創成科学研究科

    2013年6月

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    国名： 日本国

    備考： 博士(生命科学)

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  • 東京大学   大学院新領域創成科学研究科   先端生命科学専攻

    2008年4月 - 2013年3月

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    国名： 日本国

    備考： 博士課程

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  • 東京大学   大学院新領域創成科学研究科   先端生命科学専攻

    2006年4月 - 2008年3月

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    国名： 日本国

    備考： 修士課程

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  • 東京薬科大学   生命科学部

    2002年4月 - 2006年3月

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    国名： 日本国

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経歴

  • 愛媛大学   大学院医農融合公衆衛生学環   講師

    2023年9月 - 現在

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    国名：日本国

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  • 香港中文大学   医学部 ケミカルパソロジー部門   助理教授

    2020年9月 - 2023年8月

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    国名：ホンコン(香港)特別行政区

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  • シンシナティ小児病院   アレルギー & 免疫学部門   Dr.Artem Barski 研究室

    2013年10月 - 2020年7月

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    国名：アメリカ合衆国

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  • 日本学術振興会特別研究員（DC1）

    2008年4月 - 2011年3月

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    国名：日本国

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所属学協会

委員歴

  • 2022 3rd International Conference on Materials Science and Engineering   Conference Technical Committee and reviewer  

    2022年5月   

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    団体区分：学協会

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  • 2021 International Conference on Biomaterials and Applications Engineering   Conference Technical Committee and reviewer  

    2021年12月   

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    団体区分：学協会

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論文

  • ZSCAN4-binding motif - TGCACAC is conserved and enriched in CA/TG microsatellites in both mouse and human genomes.

    Akiyama T, Kei-ichiro Ishiguro, Chikazawa N, Ko SBH, Yukawa M, Minoru Ko

    DNA research : an international journal for rapid publication of reports on genes and genomes   2023年12月

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    掲載種別：研究論文（学術雑誌）  

    The Zinc finger and SCAN domain containing 4 (ZSCAN4) protein, expressed transiently in pluripotent stem cells, gametes, and early embryos, extends telomeres, enhances genome stability, and improves karyotypes in mouse embryonic stem (mES) cells. To gain insights into the mechanism of ZSCAN4 function, we identified genome-wide binding sites of endogenous ZSCAN4 protein using ChIP-seq technology in mouse and human ES cells, where the expression of endogenous ZSCAN4 was induced by treating cells with retinoic acids or by overexpressing DUX4. We revealed that both mouse and human ZSCAN4 bind to the TGCACAC motif located in CA/TG microsatellite repeats, which are known to form unstable left-handed duplexes called Z-DNA that can induce double-strand DNA breaks and mutations. These ZSCAN4 binding sites are mostly located in intergenic and intronic regions of the genomes. By generating ZSCAN4 knockout in human ES cells, we showed that ZSCAN4 does not seem to be involved in transcriptional regulation. We also found that ectopic expression of mouse ZSCAN4 enhances the suppression of chromatin at ZSCAN4-binding sites. These results together suggest that some of the ZSCAN4 functions are mediated by binding to the error-prone regions in mouse and human genomes.

    DOI： 10.1093/dnares/dsad029

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  • PRC1 suppresses a female gene regulatory network to ensure testicular differentiation.

    Maezawa S, Yukawa M, Hasegawa K, Sugiyama R, Iizuka M, Mengwen Hu, Sakashita A, Vidal M, Koseki H, Barski A, Tony DeFalco, Satoshi Namekawa

    Cell death & disease   2023年8月

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    掲載種別：研究論文（学術雑誌）  

    Gonadal sex determination and differentiation are controlled by somatic support cells of testes (Sertoli cells) and ovaries (granulosa cells). In testes, the epigenetic mechanism that maintains chromatin states responsible for suppressing female sexual differentiation remains unclear. Here, we show that Polycomb repressive complex 1 (PRC1) suppresses a female gene regulatory network in postnatal Sertoli cells. We genetically disrupted PRC1 function in embryonic Sertoli cells after sex determination, and we found that PRC1-depleted postnatal Sertoli cells exhibited defective proliferation and cell death, leading to the degeneration of adult testes. In adult Sertoli cells, PRC1 suppressed specific genes required for granulosa cells, thereby inactivating the female gene regulatory network. Chromatin regions associated with female-specific genes were marked by Polycomb-mediated repressive modifications: PRC1-mediated H2AK119ub and PRC2-mediated H3K27me3. Taken together, this study identifies a critical Polycomb-based mechanism that suppresses ovarian differentiation and maintains Sertoli cell fate in adult testes.

    DOI： 10.1038/s41419-023-05996-6

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  • An atlas of gene regulatory networks for memory CD4+T cells in youth and old age

    Joseph A. Wayman, Alyssa Thomas, Anthony Bejjani, Alexander Katko, Maha Almanan, Alzbeta Godarova, Svetlana Korinfskaya, Tareian A. Cazares, Masashi Yukawa, Leah C. Kottyan, Artem Barski, Claire A. Chougnet, David A. Hildeman, Emily R. Miraldi

    2023年3月

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  • Effects of nucleases on cell-free extrachromosomal circular DNA

    Sarah T.K. Sin, Jiaen Deng, Lu Ji, Masashi Yukawa, Rebecca W.Y. Chan, Stefano Volpi, Augusto Vaglio, Paride Fenaroli, Paola Bocca, Suk Hang Cheng, Danny K.L. Wong, Kathy O. Lui, Peiyong Jiang, K.C. Allen Chan, Rossa W.K. Chiu, Y.M. Dennis Lo

    JCI Insight   7 ( 8 )   2022年4月

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    掲載種別：研究論文（学術雑誌）   出版者・発行元：American Society for Clinical Investigation  

    DOI： 10.1172/jci.insight.156070

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  • Polycomb suppresses a female gene regulatory network to ensure testicular differentiation

    Maezawa S, Yukawa M, Hasegawa K, Sugiyama R, Hu M, Vidal M, Koseki H, Barski A, DeFalco T, Namekawa SH

    2021年1月

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    掲載種別：研究論文（学術雑誌）  

    DOI： 10.1101/2021.01.19.427322

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  • Endogenous retroviruses drive species-specific germline transcriptomes in mammals.

    Sakashita A, Maezawa S, Takahashi K, Alavattam KG, Yukawa M, Hu YC, Kojima S, Parrish NF, Barski A, Pavlicev M, Namekawa SH

    Nature structural & molecular biology   2020年9月

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    掲載種別：研究論文（学術雑誌）  

    DOI： 10.1038/s41594-020-0487-4

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  • Super-enhancer switching drives a burst in gene expression at the mitosis-to-meiosis transition.

    Maezawa S, Sakashita A, Yukawa M, Chen X, Takahashi K, Alavattam KG, Nakata I, Weirauch MT, Barski A, Namekawa SH

    Nature structural & molecular biology   27 ( 10 )   978 - 988   2020年9月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：Springer Science and Business Media {LLC}  

    DOI： 10.1038/s41594-020-0488-3

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  • Super-enhancer switching drives a burst in germline gene expression at the mitosis-to-meiosis transition

    Maezawa S, Yukawa M, Chen X, Sakashita A, Alavattam KG, Weirauch MT, Barski A, Namekawa SH

    2020年3月

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    掲載種別：研究論文（学術雑誌）  

    DOI： 10.1101/2020.03.11.987180

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  • AP-1 activity induced by co-stimulation is required for chromatin opening during T cell activation.

    Masashi Yukawa

    The Journal of experimental medicine   2020年1月

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    掲載種別：研究論文（学術雑誌）  

    Activation of T cells is dependent on the organized and timely opening and closing of chromatin. Herein, we identify AP-1 as the transcription factor that directs most of this remodeling. Chromatin accessibility profiling showed quick opening of closed chromatin in naive T cells within 5 h of activation. These newly opened regions were strongly enriched for the AP-1 motif, and indeed, ChIP-seq demonstrated AP-1 binding at >70% of them. Broad inhibition of AP-1 activity prevented chromatin opening at AP-1 sites and reduced the expression of nearby genes. Similarly, induction of anergy in the absence of co-stimulation during activation was associated with reduced induction of AP-1 and a failure of proper chromatin remodeling. The translational relevance of these findings was highlighted by the substantial overlap of AP-1-dependent elements with risk loci for multiple immune diseases, including multiple sclerosis, inflammatory bowel disease, and allergic disease. Our findings define AP-1 as the key link between T cell activation and chromatin remodeling.

    DOI： 10.1084/jem.20182009

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  • Polycomb protein SCML2 facilitates H3K27me3 to establish bivalent domains in the male germline.

    Masashi Yukawa

    Proceedings of the National Academy of Sciences of the United States of America   2018年4月

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    掲載種別：研究論文（学術雑誌）  

    Repressive H3K27me3 and active H3K4me2/3 together form bivalent chromatin domains, molecular hallmarks of developmental potential. In the male germline, these domains are thought to persist into sperm to establish totipotency in the next generation. However, it remains unknown how H3K27me3 is established on specific targets in the male germline. Here, we demonstrate that a germline-specific Polycomb protein, SCML2, binds to H3K4me2/3-rich hypomethylated promoters in undifferentiated spermatogonia to facilitate H3K27me3. Thus, SCML2 establishes bivalent domains in the male germline of mice. SCML2 regulates two major classes of bivalent domains: Class I domains are established on developmental regulator genes that are silent throughout spermatogenesis, while class II domains are established on somatic genes silenced during late spermatogenesis. We propose that SCML2-dependent H3K27me3 in the male germline prepares the expression of developmental regulator and somatic genes in embryonic development.

    DOI： 10.1073/pnas.1804512115

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  • Transcription factors operate across disease loci, with EBNA2 implicated in autoimmunity.

    Masashi Yukawa

    Nature genetics   2018年4月

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    掲載種別：研究論文（学術雑誌）  

    Explaining the genetics of many diseases is challenging because most associations localize to incompletely characterized regulatory regions. Using new computational methods, we show that transcription factors (TFs) occupy multiple loci associated with individual complex genetic disorders. Application to 213 phenotypes and 1,544 TF binding datasets identified 2,264 relationships between hundreds of TFs and 94 phenotypes, including androgen receptor in prostate cancer and GATA3 in breast cancer. Strikingly, nearly half of systemic lupus erythematosus risk loci are occupied by the Epstein-Barr virus EBNA2 protein and many coclustering human TFs, showing gene-environment interaction. Similar EBNA2-anchored associations exist in multiple sclerosis, rheumatoid arthritis, inflammatory bowel disease, type 1 diabetes, juvenile idiopathic arthritis and celiac disease. Instances of allele-dependent DNA binding and downstream effects on gene expression at plausibly causal variants support genetic mechanisms dependent on EBNA2. Our results nominate mechanisms that operate across risk loci within disease phenotypes, suggesting new models for disease origins.

    DOI： 10.1038/s41588-018-0102-3

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  • Dynamic reorganization of open chromatin underlies diverse transcriptomes during spermatogenesis.

    Maezawa S, Yukawa M, Alavattam KG, Barski A, Namekawa SH

    Nucleic acids research   2018年1月

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    掲載種別：研究論文（学術雑誌）  

    DOI： 10.1093/nar/gkx1052

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  • Polycomb directs timely activation of germline genes in spermatogenesis.

    Maezawa S, Hasegawa K, Yukawa M, Sakashita A, Alavattam KG, Andreassen PR, Vidal M, Koseki H, Barski A, Namekawa SH

    Genes & development   2017年8月

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    掲載種別：研究論文（学術雑誌）  

    DOI： 10.1101/gad.302000.117

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  • Genomic integration of Wnt/β-catenin and BMP/Smad1 signaling coordinates foregut and hindgut transcriptional programs.

    Stevens ML, Chaturvedi P, Rankin SA, Macdonald M, Jagannathan S, Yukawa M, Barski A, Zorn AM

    Development (Cambridge, England)   2017年2月

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    掲載種別：研究論文（学術雑誌）  

    DOI： 10.1242/dev.145789

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  • Functional characterization of human T cell hyporesponsiveness induced by CTLA4-Ig.

    Rochman Y, Yukawa M, Kartashov AV, Barski A

    PloS one   2015年4月

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    掲載種別：研究論文（学術雑誌）  

    DOI： 10.1371/journal.pone.0122198

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  • Genome-wide analysis of the chromatin composition of histone H2A and H3 variants in mouse embryonic stem cells.

    Yukawa M, Akiyama T, Franke V, Mise N, Isagawa T, Suzuki Y, Suzuki MG, Vlahovicek K, Abe K, Aburatani H, Aoki F

    PloS one   2014年3月

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    掲載種別：研究論文（学術雑誌）  

    DOI： 10.1371/journal.pone.0092689

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  • Changes in the nuclear deposition of histone H2A variants during pre-implantation development in mice.

    Nashun B, Yukawa M, Liu H, Akiyama T, Aoki F

    Development (Cambridge, England)   2010年10月

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    掲載種別：研究論文（学術雑誌）  

    DOI： 10.1242/dev.051805

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  • Deficiency in the response to DNA double-strand breaks in mouse early preimplantation embryos.

    Yukawa M, Oda S, Mitani H, Nagata M, Aoki F

    Biochemical and biophysical research communications   2007年5月

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    掲載種別：研究論文（学術雑誌）  

    DOI： 10.1016/j.bbrc.2007.04.162

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  • Autocrine activation of EGF receptor promotes oscillation of glutamate-induced calcium increase in astrocytes cultured in rat cerebral cortex.

    Masashi Yukawa

    Journal of neurochemistry   2005年8月

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    掲載種別：研究論文（学術雑誌）  

    We previously reported that astrocytes cultured for more than 2 days in a defined medium containing epidermal growth factor (EGF) and basic fibroblast growth factor (bFGF) showed calcium oscillation in response to glutamate, whereas the response pattern was transient in the absence of the exogenous growth factors. In the present study, we found that astrocytes showed glutamate-induced calcium oscillation, even in growth factor-free medium, if the cells had been cultured for more than 5 days. The calcium oscillation promoted by the prolonged culture period was suppressed by an inhibitor of EGF receptor tyrosine kinase, but not by a neutralizing antibody to bFGF, indicating that the accumulation of an autocrine factor that activates the EGF receptor leads to calcium oscillation. Astrocytes in our culture system expressed EGF, transforming growth factor alpha (TGFalpha), bFGF and acidic fibroblast growth factor (aFGF). Exogenous aFGF, which induced astrocyte immediate early gene expression to the same extent as EGF or bFGF, did not affect calcium oscillation. Exogenous EGF and bFGF promoted astrocyte hypertrophic morphology and proliferation, as well as calcium oscillation. In contrast, these properties did not accompany calcium oscillation induced by the prolonged culture period. These results suggest that astrocytes possess the ability to promote their own calcium oscillation, which is independent of hypertrophic changes to reactive astrocytes.

    DOI： 10.1111/j.1471-4159.2005.03430.x

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書籍等出版物

  • sharing career path experience

    https, note.com/uja_career

    United Japanese researchers Abroad  2022年 

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  • Merit and demerit in doing researches in outside of Japan.

    Jikkenigaku X United Japanese researchers Abroad (UJA) web column project  2015年 

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講演・口頭発表等

  • Research talk for special lecture in University of Yamanashi Special Education Program for Development and Practice of Developmental Engineering Technology 招待

    Masashi Yukawa

    Research talk for special lecture in University of Yamanashi Special Education Program for Development and Practice of Developmental Engineering Technology  2021年10月 

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    会議種別：公開講演，セミナー，チュートリアル，講習，講義等  

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  • Research talk for Department of Animal Science and Biotechnology in Azabu University 招待

    Masashi Yukawa

    Research talk for Department of Animal Science and Biotechnology in Azabu University  2019年 

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    会議種別：公開講演，セミナー，チュートリアル，講習，講義等  

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  • Research talk and career plan in overseas for UC-tomorrow

    Masashi Yukawa

    Research talk and career plan in overseas for UC-tomorrow  2022年6月 

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    会議種別：公開講演，セミナー，チュートリアル，講習，講義等  

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  • Systems Biology lecture in Tokyo University of Science 招待

    Masashi Yukawa

    Systems Biology lecture in Tokyo University of Science  2022年10月 

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    会議種別：公開講演，セミナー，チュートリアル，講習，講義等  

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  • Career talk in Tobitate! Study Abroad JAPAN "Unraveling the Relationship between Studying and Entering Universities Abroad and Careers”. 招待

    Masashi Yukawa

    Tobitate! Study Abroad JAPAN  2022年6月 

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    会議種別：公開講演，セミナー，チュートリアル，講習，講義等  

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  • lecture of SCMI 624 Special Topics in Microbiology and Immunology, The Faculty of Graduate Studies, Mahidol University. Bangkok, Thai 招待

    Masashi Yukawa

    lecture of SCMI 624 Special Topics in Microbiology and Immunology, The Faculty of Graduate Studies, Mahidol University. Bangkok, Thai  2023年 

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    会議種別：公開講演，セミナー，チュートリアル，講習，講義等  

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  • Special talk 「Regulation of transcriptional program through chromatin structure in T cell activation」 招待

    Masashi Yukawa

    Department of Microbiology, Faculty of Medicine, Chiang Mai University. Chiang Mai, Thai  2023年 

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    会議種別：公開講演，セミナー，チュートリアル，講習，講義等  

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  • Research talk for School of Medicine in Keio University 招待

    Masashi Yukawa

    Research talk for School of Medicine in Keio University  2019年 

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    会議種別：公開講演，セミナー，チュートリアル，講習，講義等  

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受賞

  • Outstanding Paper Award

    2022年   United Japanese researchers Around the world  

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  • Presentation award

    2019年   UJA Midwest conference  

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  • Travel award for Early Career Researchers in Overseas

    2019年   The Molecular Biology Society of Japan  

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  • Presentation award

    2017年   UJA Midwest conference  

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  • Travel award for Early Career Researchers in Overseas

    2016年   The Molecular Biology Society of Japan  

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  • Abstract award

    2016年   UJA Midwest conference  

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  • Careers in Immunology Fellowships

    2015年   American Association of Immunologist  

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  • Research Award

    2011年   Global COE Program at The University of Tokyo  

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共同研究・競争的資金等の研究課題

  • 血液細胞表面DNAを活用した多様な疾患の早期発見に向けた新たな医工計測法の提案

    2023年12月 - 2024年11月

    鈴木謙三記念医科学応用研究財団  調査研究助成 

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    担当区分：研究代表者 

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  • クロマチン高次構造によるヘルパーT細胞の遺伝子発現制御機構の解明とアレルギー疾患への影響

    2023年11月 - 2024年10月

    公益財団法人 持田記念医学薬学振興財団  研究助成 

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    担当区分：研究代表者 

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  • 新規健康診断のための細胞表面DNAを用いた非侵襲的な医工計測法の開発

    2023年9月 - 2024年8月

    公益財団法人天野工業技術研究所  2023年後期 研究助成 

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    担当区分：研究代表者 

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その他

  • Cincinnati Children’s Hospital Newsroom announced my research work as outstanding work

    2020年

    　詳細を見る

    https:/¬/www.cincinnatichildrens.org/news/release/2019/immune-diseases

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  • preLights selected my research paper as outstanding work.

    2019年

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    https://prelights.biologists.com/highlights/co-stimulation-induced-ap-1-activity-is-required-for-chromatin-opening-during-t-cell-activation/

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担当経験のある科目（授業）

  • Immunotherapy lecture

    2021年 - 2023年 機関名：The Chinese University of Hong Kong

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  • B cell Immunology lecture

    2020年 - 2023年 機関名：The Chinese University of Hong Kong

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  • Immunology laboratory practice

    2020年 - 2023年 機関名：The Chinese University of Hong Kong

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  • Immunology tutorial

    2020年 - 2023年 機関名：The Chinese University of Hong Kong

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  • Introduction of immunology lecture

    2020年 - 2023年 機関名：The Chinese University of Hong Kong

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メディア報道

  • Cincinnati Children’s Hospital Newsroom announced outstanding work インターネットメディア

    Cincinnati Children’s Hospital Newsroom  https:/¬/www.cincinnatichildrens.org/news/release/2019/immune-diseases  2020年

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    執筆者：本人以外 

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  • F1000prime selected research paper as a significant paper インターネットメディア

    F1000prime  https://f1000.com/prime/736814040?subscriptioncode=8391a0a8-068e-43ed-89be-f675024d6aac&utm_medium=email&utm_source=prime_ypp  2020年

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    執筆者：本人以外 

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  • preLights selected outstanding work インターネットメディア

    preLights  https://prelights.biologists.com/highlights/co-stimulation-induced-ap-1-activity-is-required-for-chromatin-opening-during-t-cell-activation/  2019年

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    執筆者：本人以外 

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学術貢献活動

  • In Silico Infection Analysis (iSFA) Identified Coronavirus Infection and Potential Transmission Risk in Mammals

    役割：査読

    Front. Mol. Biosci.  2022年2月

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    種別：査読等 

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