2025/03/27 更新

写真a

イノウエ カツジ
井上 勝次
Inoue Katsuji
所属
大学院医学系研究科 医学専攻 教授
職名
教授
連絡先
メールアドレス
外部リンク

学位

  • 特発性拡張型心筋症における心筋微小循環障害は心事故と関連する ( 2004年3月   愛媛大学 )

研究キーワード

  • 超音波心エコー図学

  • 心不全

  • 左房機能

研究分野

  • ライフサイエンス / 循環器内科学

研究テーマ

  • 超音波心エコー図検査を用いた心不全診断と予後調査

経歴

  • 愛媛大学大学院医学系研究科   地域救急医療学講座   教授

    2023年12月 - 現在

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  • 愛媛大学大学院循環器・呼吸器・腎高血圧内科学   准教授

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取得資格

  • 医師免許

論文

  • Echocardiographic Evaluation of Left Ventricular Filling Pressure in Patients With Pulmonary Hypertension

    Katsuji Inoue, Oyvind S. Andersen, Espen W. Remme, Faraz H. Khan, Arne K. Andreassen, Helge Skulstad, Einar Gude, Otto A. Smiseth

    JACC: Cardiovascular Imaging   17 ( 5 )   566 - 567   2024年5月

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    担当区分:筆頭著者   掲載種別:研究論文(学術雑誌)   出版者・発行元:Elsevier BV  

    DOI: 10.1016/j.jcmg.2023.12.004

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  • A prediction model for estimating NT-proBNP in a general Japanese population: the Toon Health Study. 国際誌

    Katsuji Inoue, Kazumichi Yamamoto, Haruhiko Higashi, Yasunori Takata, Shinji Inaba, Shigehiro Miyazaki, Akinori Higaki, Makoto Saito, Haruhiko Osawa, Osamu Yamaguchi

    ESC heart failure   2024年2月

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    担当区分:筆頭著者   記述言語:英語   掲載種別:研究論文(学術雑誌)  

    AIMS: As part of the Toon Health Study, which is an ongoing population-based cohort study, we aimed to develop a prediction model for N-terminal pro-brain natriuretic peptide (NT-proBNP) in a general Japanese population. We sought to explore the influence of various demographic and clinical factors on NT-proBNP levels and assess the model's performance. In addition, our objectives included internal validation and investigation of the diagnostic potential of the observed-to-predicted NT-proBNP ratio (OPR) at baseline for predicting the risk of heart failure with preserved ejection fraction (HFpEF). METHODS AND RESULTS: In this prospective cohort study, participants were recruited from Toon City, Japan, as part of the larger Toon Health Study, focusing on cardiovascular risk factors. We measured the NT-proBNP levels and used linear regression with penalization (ridge regression) to develop the model. The model incorporated 10 prespecified predictors (age, gender, body mass index, diastolic blood pressure, heart rate, haemoglobin, albumin, total cholesterol, haemoglobin A1c, and estimated glomerular filtration rate) and underwent assessment using R2 and root mean squared error (RMSE). Internal validation was conducted through bootstrapping. In a post hoc analysis, we explored the OPR's diagnostic potential using 5 year follow-up data (n = 636) to predict the elevation of NT-proBNP > 125 pg/mL at the 5 year follow-up as the risk of HFpEF. A total of 2505 participants (age: 60.4 ± 12.9 years, men: 35%) were enrolled in this study. There was a linear relationship between the observed and predicted values of NT-proBNP in which the logarithm of observed NT-proBNP was <6, which corresponds to 403 pg/mL in NT-proBNP. The prediction model demonstrated satisfactory performance (R2 : 0.291, RMSE: 0.688), with age identified as a dominant predictor. The stability of the model was underscored by the internal validation. The OPR at baseline predicted NT-proBNP > 125 pg/mL at the 5 year follow-up with an area under the curve of 0.793. CONCLUSIONS: This study introduces the first prediction model for NT-proBNP in a general Japanese population. Although the model has acceptable performance, ongoing refinement is essential. Our transparent approach to model development, alongside a web-based interactive tool, lays the groundwork for further improvements and external validation. The OPR holds potential for predicting the future risk of HFpEF. This research contributes to understanding the nuanced influence of patient backgrounds on levels of NT-proBNP in asymptomatic individuals within the context of a broader population-based cohort study.

    DOI: 10.1002/ehf2.14691

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  • Left atrium as key player and essential biomarker in heart failure 招待 査読

    Katsuji Inoue, Otto A Smiseth

    2024年

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    担当区分:筆頭著者   記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.jjcc.2024.07.006.

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  • Echocardiographic Assessment of Atrial Function: From Basic Mechanics to Specific Cardiac Diseases. 国際誌

    Katsuji Inoue, Hiroshi Kawakami, Yusuke Akazawa, Haruhiko Higashi, Takashi Higaki, Osamu Yamaguchi

    Journal of cardiovascular development and disease   9 ( 3 )   2022年2月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    The left and right atria serve as buffer chambers to control the flow of venous blood for ventricular filling. If an atrium is absent, blood does not flow effectively into the ventricle, leading to venous blood retention and low cardiac output. The importance of atrial function has become increasingly recognized, because left atrial (LA) function contributes to cardiac performance, and loss of LA function is associated with heart failure. LA volume change has been used for LA function assessment in experimental and clinical studies. In conjunction with LA pressure, the LA pressure-volume relationship provides a better understanding of LA mechanics. LA strain measurement by speckle tracking echocardiography was introduced to evaluate three components of LA function as a (booster) pump, reservoir and conduit. Furthermore, increasing evidence supports the theory that LA reservoir strain has prognostic utility in various cardiac diseases. In this review, we summarize LA contribution to maintain cardiac performance by evaluating LA function with echocardiography according to our experiences and previous reports. Furthermore, we discuss LA dysfunction in challenging cardiac diseases of cardiac amyloidosis and adult congenital heart disease.

    DOI: 10.3390/jcdd9030068

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  • Persistence of left atrial abnormalities despite left atrial volume normalization after successful ablation of atrial fibrillation.

    Hiroshi Kawakami, Katsuji Inoue, Takayuki Nagai, Akira Fujii, Yasuhiro Sasaki, Yukari Shikano, Namiko Sakuoka, Maki Miyazaki, Yasunori Takasuka, Shuntaro Ikeda, Osamu Yamaguchi

    Journal of arrhythmia   37 ( 5 )   1318 - 1329   2021年10月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    BACKGROUND: Left atrial volume index (LAVI) of >34 mL/m2 is the cutoff value for identifying an enlarged left atrium. The definition of left atrial (LA) reverse remodeling after atrial fibrillation (AF) ablation is undetermined. We hypothesized that patients with LA dilatation who achieve normal LA volume (LAVI<34 mL/m2) after AF ablation have better long-term outcomes than those who do not. Furthermore, we investigated whether patients with a normal LA volume can also achieve normal LA function with AF ablation. METHODS: We enrolled 140 AF patients with baseline LAVI of ≥34 mL/m2, without AF recurrence for 1 year after the initial AF ablation. We acquired conventional and speckle-tracking echocardiographic parameters within 24 hour and at 1 year after the procedure. To define the normal range of LA function, age- and sex-matched controls without a history of AF were also enrolled. RESULTS: After restoration of sinus rhythm, LA structural and functional parameters significantly improved, and 75 patients (54%) had normal LA volume. During a median follow-up of 44 (31-61) months, 32 patients (23%) experienced a late recurrence of AF (AF recurrence >1 year). Patients who achieved normal LA volume after AF ablation had fewer late recurrences than those who did not (P < .01). However, LA abnormalities, especially LA dysfunction, persisted in AF patients even when the LA volume was normalized compared with controls. CONCLUSION: Patients who achieved normal LA volume had better long-term outcomes of AF ablation than those who did not; however, LA abnormalities persisted even after successful ablation of AF.

    DOI: 10.1002/joa3.12624

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  • Restricted left atrial dilatation can visually differentiate cardiac amyloidosis from hypertrophic cardiomyopathy. 国際誌

    Haruhiko Higashi, Katsuji Inoue, Shinji Inaba, Yasuhisa Nakao, Masaki Kinoshita, Shigehiro Miyazaki, Toru Miyoshi, Yusuke Akazawa, Hiroshi Kawakami, Teruyoshi Uetani, Jun Aono, Takayuki Nagai, Kazuhisa Nishimura, Shuntaro Ikeda, Makoto Saito, Osamu Yamaguchi

    ESC heart failure   8 ( 4 )   3198 - 3205   2021年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    AIMS: Cardiac amyloidosis (CA) is an infiltrative myocardial disease that occasionally mimics hypertrophic cardiomyopathy (HCM). The aim of this study is to investigate the discriminatory ability of visual assessment of left atrial (LA) function between CA and HCM on echocardiography. METHODS AND RESULTS: In total, 93 patients with cardiac magnetic resonance imaging (CMR)-confirmed HCM and 34 with cardiac biopsy-confirmed CA were retrospectively assessed. LA dilatation was assessed via echocardiography in an apical four-chamber view. Visual assessment was performed to identify LA dilatation grade (preserved = 1, abnormal = 2, and restricted = 3) based on the extent of outward expansion in the LA reservoir phase. Regarding the reproducibility of visually assessing LA dilatation grade, the kappa values between intra- and inter-observer measurements were 0.82 and 0.70, respectively. Of 127 participants, 57 (45%), 42 (33%), and 28 (22%) presented with LA dilatation Grades 1, 2, and 3, respectively. All 57 patients with preserved LA dilatation (Grade 1) had HCM, and 20 of 28 patients (71%) with restricted LA dilatation (Grade 3) presented with CA. Patients with CA had a higher LA dilatation grade than those with HCM (P < 0.01). LA emptying fraction and reservoir strain were also quantitatively evaluated. The area under the curves of LA dilatation grade (0.88) and LA emptying fraction (0.88) for differentiation of these two diseases were higher than that of LA reservoir strain (0.73) (P < 0.01, respectively). During follow-up, nine patients with HCM and 16 with CA experienced cardiac event (cardiac death or hospitalization due to heart failure). In Kaplan-Meier analysis including both groups of HCM and CA, the incidence of cardiac events was higher in patients with restricted LA dilatation than in those with preserved or abnormal LA dilatation (log-rank test, P < 0.01). CONCLUSIONS: Restricted LA dilatation is an indicator for the diagnosis of CA. Further, visual assessment of abnormal LA motion may facilitate diagnosis in patients with CA and high-risk patients with HCM.

    DOI: 10.1002/ehf2.13442

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  • Determinants of left atrial reservoir and pump strain and use of atrial strain for evaluation of left ventricular filling pressure

    Katsuji Inoue, Faraz H Khan, Espen W Remme, Nobuyuki Ohte, Eusebio García-Izquierdo, Michael Chetrit, Vanessa Moñivas-Palomero, Susana Mingo-Santos, Øyvind S Andersen, Einar Gude, Arne K Andreassen, Tom Kai Ming Wang, Shohei Kikuchi, Marie Stugaard, Jong-Won Ha, Allan L Klein, Sherif F Nagueh, Otto A Smiseth

    European Heart Journal - Cardiovascular Imaging   23 ( 1 )   61 - 70   2021年1月

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    担当区分:筆頭著者   掲載種別:研究論文(学術雑誌)   出版者・発行元:Oxford University Press (OUP)  

    Abstract

    Aims

    The aim of this study is to investigate determinants of left atrial (LA) reservoir and pump strain and if these parameters may serve as non-invasive markers of left ventricular (LV) filling pressure.

    Methods and results

    In a multicentre study of 322 patients with cardiovascular disease of different aetiologies, LA strain and other echocardiographic parameters were compared with invasively measured LV filling pressure. The strongest determinants of LA reservoir and pump strain were LV global longitudinal strain (GLS) (r-values 0.64 and 0.51, respectively) and LV filling pressure (r-values −0.52 and −0.57, respectively). Left atrial volume was another independent, but weaker determinant of both LA strains. For both LA strains, association with LV filling pressure was strongest in patients with reduced LV ejection fraction. Left atrial reservoir strain &amp;lt;18% and LA pump strain &amp;lt;8% predicted elevated LV filling pressure better (P &amp;lt; 0.05) than LA volume and conventional Doppler parameters. Accuracy to identify elevated LV filling pressure was 75% for LA reservoir strain alone and 72% for pump strain alone. When combined with conventional parameters, accuracy was 82% for both LA strains. In patients with normal LV systolic function by GLS, LA pump strain &amp;gt;14% identified normal LV filling pressure with 92% accuracy.

    Conclusion

    Left atrial reservoir and pump strain are determined predominantly by LV GLS and filling pressure. Accuracy of LA strains to identify elevated LV filling pressure was best in patients with reduced LV systolic function. High values of LA pump strain, however, identified normal LV filling pressure with good accuracy in patients with normal systolic function.

    DOI: 10.1093/ehjci/jeaa415

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  • Safety and Efficacy of Imeglimin for Type 2 Diabetes Mellitus in Patients With Heart Failure. 国際誌

    Tomoaki Nishikawa, Akinori Higaki, Keisho Kurokawa, Kohei Yoshimoto, Rikako Horie, Yasuhisa Nakao, Tomoki Fujisawa, Shigehiro Miyazaki, Yusuke Akazawa, Toru Miyoshi, Hiroshi Kawakami, Haruhiko Higashi, Shunsuke Tamaki, Kazuhisa Nishimura, Katsuji Inoue, Shuntaro Ikeda, Osamu Yamaguchi

    In vivo (Athens, Greece)   39 ( 1 )   375 - 380   2025年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    BACKGROUND/AIM: Imeglimin, a novel oral antidiabetic agent, was approved in 2021 for the treatment of type 2 diabetes mellitus (T2DM). Phase III clinical trials demonstrated its safety and efficacy in managing T2DM. However, its safety profile in patients with heart failure has not been thoroughly evaluated in real-world clinical settings. PATIENTS AND METHODS: We analyzed cases of patients with heart failure (stage B or higher) who were newly prescribed imeglimin, based on electronic medical records from June 2022 to June 2024. Baseline clinical data at the initiation of imeglimin therapy were collected, and cardiovascular events, adverse effects (e.g., lactic acidosis), and blood test results, including glycated hemoglobin A1c (HbA1c), were assessed as of July 2024. RESULTS: A total of 21 patients met the inclusion criteria. HbA1c levels significantly decreased after an average of 312.1±205.8 days of imeglimin therapy (baseline vs. on therapy: 8.2±1.0% vs. 7.5±0.7%, p=0.001). Alanine aminotransferase levels were also significantly reduced (baseline vs. on therapy: 30.9±23.8 IU/l vs. 22.0±12.3 IU/l, p=0.022). No adverse drug reactions were observed during the treatment period. Major adverse cardiovascular events occurred in three patients (14%), although a clear association with imeglimin remains uncertain. CONCLUSION: Imeglimin demonstrated safety and efficacy in T2DM in patients with coexisting heart failure.

    DOI: 10.21873/invivo.13838

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  • Excessive supraventricular ectopic activity is a simple cutoff for predicting late recurrence of atrial fibrillation after ablation.

    Tomoki Fujisawa, Hiroshi Kawakami, Shunsuke Tamaki, Shigehiro Miyazaki, Yusuke Akazawa, Toru Miyoshi, Akinori Higaki, Fumiyasu Seike, Haruhiko Higashi, Kazuhisa Nishimura, Katsuji Inoue, Shuntaro Ikeda, Osamu Yamaguchi

    Heart and vessels   2024年12月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    The relationship between post-ablation excessive supraventricular ectopic activity (ESVEA), a new marker for new-onset atrial fibrillation (AF), and late AF recurrence is uncertain. We enrolled 469 patients with AF who underwent initial radiofrequency catheter ablation and 24-h Holter monitoring the day after. Early AF recurrence (n = 57; 12%) and ESVEA (n = 242; 52%) were noted. During a median follow-up of 25 months, 152 (32%) patients experienced late AF recurrence. Patients with early AF recurrence or ESVEA were significantly more likely to experience late recurrence (p = 0.02). Even without AF, ESVEA was associated with late recurrence following AF ablation.

    DOI: 10.1007/s00380-024-02498-z

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  • Remote dielectric sensing predicts elevated left atrial pressure in patients with atrial fibrillation. 国際誌

    Shunsuke Tamaki, Katsuji Inoue, Hiroshi Kawakami, Tomoki Fujisawa, Ryo Miyabe, Yasuhisa Nakao, Shigehiro Miyazaki, Yusuke Akazawa, Toru Miyoshi, Akinori Higaki, Fumiyasu Seike, Haruhiko Higashi, Kazuhisa Nishimura, Shuntaro Ikeda, Osamu Yamaguchi

    International journal of cardiology. Heart & vasculature   53   101459 - 101459   2024年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    BACKGROUND: There are currently no established non-invasive indices of echocardiography for elevated left atrial pressure (LAP) especially in patients with atrial fibrillation (AF). Remote dielectric sensing (ReDS) is a novel non-invasive electromagnetic energy-based technology that quantifies total lung fluid, enabling the monitoring of volume status in patients with heart failure. The utility of ReDS for estimating LAP in patients with AF remains unknown. METHODS: We prospectively investigated patients with AF in whom LAP was directly measured during catheter ablation for AF, and ReDS measurements were conducted the day before ablation. Elevated LAP was defined as LAP ≥ 15 mmHg. RESULTS: A total of 61 patients were included (median age 66 years, 38 % female). Among them, 26 patients had elevated LAP. There was a positive correlation between ReDS and LAP (r = 0.363, P = 0.004). Receiver operating characteristic curve analysis for the prediction of elevated LAP demonstrated that the best cut-off value of ReDS was 30 %, with a sensitivity of 65 %, specificity of 69 %, and an area under the curve of 0.703 (95 % confidence interval 0.568-0.837). Multivariate logistic regression analysis revealed that ReDS was an independent predictor of elevated LAP, among covariates including left ventricular ejection fraction, the ratio of early transmitral flow velocity to septal mitral annular early diastolic velocity, and left atrial volume index. CONCLUSIONS: Our results suggest ReDS could be a valuable marker of elevated LAP even in patients with AF. Further studies are needed to elucidate the effectiveness of a ReDS-guided decongestive strategy in patients with heart failure.

    DOI: 10.1016/j.ijcha.2024.101459

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  • Impact of Aromatase Inhibitors Treatment Duration on Coronary Artery Calcification in Postoperative Patients With Breast Cancer. 国際誌

    Yu Hiasa, Akinori Higaki, Yoshiaki Kamei, Tomoaki Nishikawa, Ryo Miyabe, Tomoki Fujisawa, Shigehiro Miyazaki, Yusuke Akazawa, Toru Miyoshi, Hiroshi Kawakami, Fumiyasu Seike, Haruhiko Higashi, Shunsuke Tamaki, Kazuhisa Nishimura, Katsuji Inoue, Shuntaro Ikeda, Osamu Yamaguchi

    The Canadian journal of cardiology   2024年7月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    BACKGROUND: Aromatase inhibitors (AIs) are the standard therapeutic approach for hormone receptor-positive postmenopausal breast cancer. However, there are concerns about increased cardiovascular risk due to their antioestrogenic effects. This study aimed to investigate the potential association between duration of AI treatment and the severity of coronary artery calcification (CAC). METHODS: The study included outpatients who initiated adjuvant endocrine therapy with AIs for breast cancer from August 2010 to October 2022. CAC was quantified according to a visual ordinal scoring system. Patient characteristics were assessed based on the presence of CAC. Independent risk factors for elevated CAC scores were identified through a multivariable logistic regression model. RESULTS: Among 357 patients, 44.8% exhibited CAC. No significant difference in AI treatment duration was observed between groups (1268 d [interquartile range (IQR) 725-1743 d] vs 1104 d [IQR 685-1683.25 d]; P = 0.236). Patients with CAC were characterised by higher age (63.06 y [56.81-68.78 y] vs 74.39 y [68.98-80.03 y]; P < 0.001), lower hemoglobin levels (g/dL: 13.20L [IQR 12.60-13.70L] vs 12.60 [IQR 11.60-13.43]; P < 0.001), and reduced estimated glomerular filtration rate (mL/min/1.73 m2: 72.00 [IQR 61.80-81.50] vs 62.80 [IQR 51.27-71.90]; P < 0.001) compared with those without CAC. The prevalences of hypertension, diabetes mellitus, and dyslipidemia were significantly higher in patients with CAC. No correlation was found between the duration of AI treatment and CAC score (R = -0.02; P = 0.78). Independent risk factors for CAC included higher age, lower hemoglobin levels, and the presence of hypertension and diabetes mellitus in postoperative patients with breast cancer. CONCLUSIONS: The duration of AI treatment does not exert a significant influence on CAC in postoperative patients with breast cancer.

    DOI: 10.1016/j.cjca.2024.05.012

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  • IVLによりステントレスPCIが可能であった冠動脈石灰化結節病変の一例

    小西 里奈, 檜垣 彰典, 日浅 悠, 仁志川 知晃, 宮部 亮, 宮崎 慈大, 藤澤 友輝, 赤澤 祐介, 三好 徹, 川上 大志, 清家 史靖, 玉置 俊介, 西村 和久, 井上 勝次, 池田 俊太郎, 山口 修

    日本心血管インターベンション治療学会抄録集   32回   MI5 - 7   2024年7月

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    記述言語:英語   出版者・発行元:(一社)日本心血管インターベンション治療学会  

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  • Predictive Value of Bioelectrical Impedance Analysis-Derived Extracellular Volume Status for Cardiac Congestion in General Cardiovascular Disease Patients(タイトル和訳中)

    宮崎 慈大, 檜垣 彰典, 日浅 悠, 神山 雅喜, 宮部 亮, 中尾 恭久, 藤澤 友輝, 赤澤 祐介, 三好 徹, 川上 大志, 清家 史靖, 東 晴彦, 玉置 俊介, 西村 和久, 井上 勝次, 池田 俊太郎, 山口 修

    日本循環器学会学術集会抄録集   88回   PJ055 - 3   2024年3月

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    記述言語:英語   出版者・発行元:(一社)日本循環器学会  

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  • Huge Right Coronary Artery Aneurysm in Mixed Connective Tissue Disease.

    Haruhiko Higashi, Chiharuko Iio, Shuntaro Ikeda, Teruyoshi Uetani, Shinji Inaba, Katsuji Inoue, Tomohisa Sakaue, Hironori Izutani, Osamu Yamaguchi

    Circulation journal : official journal of the Japanese Circulation Society   86 ( 5 )   881 - 881   2022年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1253/circj.CJ-21-1001

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  • Lung Cancer in the Left Atrium.

    Shigehiro Miyazaki, Shinji Inaba, Katsuji Inoue, Osamu Yamaguchi, Shoichi Matsukage, Akiyoshi Ogimoto

    Circulation journal : official journal of the Japanese Circulation Society   86 ( 5 )   878 - 878   2022年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1253/circj.CJ-21-0946

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  • Cost-Effectiveness of long-term tolvaptan administration for chronic heart failure treatment in Japan. 国際誌

    Yasuhisa Nakao, Hiroshi Kawakami, Makoto Saito, Katsuji Inoue, Shuntaro Ikeda, Osamu Yamaguchi

    Journal of cardiology   79 ( 3 )   408 - 416   2022年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    BACKGROUND: Tolvaptan (TLV) is effective for acute heart failure (HF) with congestion, but its long-term administration in patients with chronic HF (CHF) remains controversial. Moreover, the cost-effectiveness of TLV for CHF treatment has not yet been investigated. Thus, we sought to validate the cost-effectiveness of TLV for CHF treatment in Japan. METHODS: A Markov model was developed to compare total costs, quality-adjusted life years (QALYs), and incremental cost-effectiveness ratio (ICER) between long-term TLV strategy and the standard strategy using furosemide for CHF. The target population included 75-year-old patients with CHF. The effectiveness of the TLV strategy for CHF treatment was determined based on a systematic review and meta-analysis. We used a 10-year horizon, with sensitivity analyses for significant variables and a scenario analysis for patients with CHF receiving high-dose furosemide (≥60 mg per day). RESULTS: In the base case analysis, the total cost of the long-term TLV strategy was higher than that of the standard strategy (\3,243,779 vs. \1,179,964). The total QALYs of the long-term TLV strategy were lower than those of the standard strategy (4.52 vs 4.59). Thus, a standard TLV prescription for CHF treatment has no clinical or economic benefit. In the scenario analysis (i.e. in patients with CHF receiving high-dose furosemide), the long-term TLV strategy was more effective (total QALYs, 5.10 vs. 4.41) but more expensive (total costs, \3,540,558 vs. \1,272,208) than the standard strategy. The ICER of the TLV strategy against the standard strategy (\3,289,579/QALY) was below the willingness-to-pay of \5,000,000, which suggests that the long-term TLV strategy is cost-effective relative to the standard strategy in patients with CHF receiving high-dose furosemide. CONCLUSIONS: Long-term TLV administration did not provide a clear benefit for all patients with CHF. However, this treatment strategy may be a cost-effective therapeutic option for patients who require high-dose furosemide.

    DOI: 10.1016/j.jjcc.2021.10.026

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  • Usefulness of intravascular ultrasound assessment after development of the slow flow phenomenon during percutaneous coronary intervention. 国際誌

    Yasuhisa Nakao, Shinji Inaba, Masaki Kinoshita, Takumi Sumimoto, Makoto Saito, Jun Aono, Katsuji Inoue, Shuntaro Ikeda, Osamu Yamaguchi

    Coronary artery disease   33 ( 4 )   302 - 310   2022年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    The slow flow phenomenon is a critical complication during percutaneous coronary intervention (PCI) that leads to poor outcomes. We aimed to evaluate the mechanisms underlying the slow flow phenomenon using intravascular ultrasound (IVUS). We retrospectively analyzed IVUS data from 62 lesions in 58 consecutive patients who experienced the slow flow phenomenon during PCI. IVUS was performed immediately after the development of the slow flow phenomenon to assess its cause. No IVUS-based evidence of mechanical obstruction was categorized as distal embolization. Distal embolization was observed in 46 lesions (74%). The slow flow phenomenon occurred in all these lesions after stent implantation. In addition to distal embolization, three different mechanisms underlying the induction of the slow flow phenomenon due to mechanical obstructions (16 lesions, 26%) were detected on IVUS, namely, medial dissection/hematoma (6 lesions), intimal flap (6 lesions), and thrombus obstruction (4 lesions). Most mechanical obstructions (13 lesions, 81%) could not be identified by angiography alone. In 15/16 lesions (94%) with mechanical obstruction, deteriorated flow improved immediately after balloon dilatation or bail-out stent implantation, although intracoronary vasodilator administration could not reestablish coronary flow. The frequency of mechanical obstruction as the cause of the slow flow phenomenon was relatively high. Given the difficulty in angiographical differentiation, IVUS-guided management of slow flow may be a useful strategy.

    DOI: 10.1097/MCA.0000000000001126

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  • O-ring-induced transverse aortic constriction (OTAC) is a new simple method to develop cardiac hypertrophy and heart failure in mice. 国際誌

    Yasuhisa Nakao, Jun Aono, Mika Hamaguchi, Kayo Takahashi, Tomohisa Sakaue, Katsuji Inoue, Shuntaro Ikeda, Osamu Yamaguchi

    Scientific reports   12 ( 1 )   85 - 85   2022年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Suture-based transverse aortic constriction (TAC) in mice is one of the most frequently used experimental models for cardiac pressure overload-induced heart failure. However, the incidence of heart failure in the conventional TAC depends on the operator's skill. To optimize and simplify this method, we proposed O-ring-induced transverse aortic constriction (OTAC) in mice. C57BL/6J mice were subjected to OTAC, in which an o-ring was applied to the transverse aorta (between the brachiocephalic artery and the left common carotid artery) and tied with a triple knot. We used different inner diameters of o-rings were 0.50 and 0.45 mm. Pressure overload by OTAC promoted left ventricular (LV) hypertrophy. OTAC also increased lung weight, indicating severe pulmonary congestion. Echocardiographic findings revealed that both OTAC groups developed LV hypertrophy within one week after the procedure and gradually reduced LV fractional shortening. In addition, significant elevations in gene expression related to heart failure, LV hypertrophy, and LV fibrosis were observed in the LV of OTAC mice. We demonstrated the OTAC method, which is a simple and effective cardiac pressure overload method in mice. This method will efficiently help us understand heart failure (HF) mechanisms with reduced LV ejection fraction (HFrEF) and cardiac hypertrophy.

    DOI: 10.1038/s41598-021-04096-9

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  • 重症肺高血圧を合併したAP windowに対する治療戦略

    赤澤 祐介, 檜垣 高史, 東 晴彦, 河本 敦, 千阪 俊行, 太田 雅明, 高田 秀実, 坂本 裕司, 手島 真弓, 打田 俊司, 井上 勝次, 池田 俊太郎, 江口 真理子, 山口 修

    日本成人先天性心疾患学会雑誌   11 ( 1 )   179 - 179   2022年1月

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    記述言語:日本語   出版者・発行元:日本成人先天性心疾患学会  

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  • O-ring-induced transverse aortic constriction (OTAC) is a new simple method to develop cardiac hypertrophy and heart failure in mice

    Yasuhisa Nakao, Jun Aono, Mika Hamaguchi, Kayo Takahashi, Tomohisa Sakaue, Katsuji Inoue, Shuntaro Ikeda, Osamu Yamaguchi

    SCIENTIFIC REPORTS   12 ( 1 )   2022年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:NATURE PORTFOLIO  

    Suture-based transverse aortic constriction (TAC) in mice is one of the most frequently used experimental models for cardiac pressure overload-induced heart failure. However, the incidence of heart failure in the conventional TAC depends on the operator's skill. To optimize and simplify this method, we proposed O-ring-induced transverse aortic constriction (OTAC) in mice. C57BL/6J mice were subjected to OTAC, in which an o-ring was applied to the transverse aorta (between the brachiocephalic artery and the left common carotid artery) and tied with a triple knot. We used different inner diameters of o-rings were 0.50 and 0.45 mm. Pressure overload by OTAC promoted left ventricular (LV) hypertrophy. OTAC also increased lung weight, indicating severe pulmonary congestion. Echocardiographic findings revealed that both OTAC groups developed LV hypertrophy within one week after the procedure and gradually reduced LV fractional shortening. In addition, significant elevations in gene expression related to heart failure, LV hypertrophy, and LV fibrosis were observed in the LV of OTAC mice. We demonstrated the OTAC method, which is a simple and effective cardiac pressure overload method in mice. This method will efficiently help us understand heart failure (HF) mechanisms with reduced LV ejection fraction (HFrEF) and cardiac hypertrophy.

    DOI: 10.1038/s41598-021-04096-9

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  • 脳膿瘍を契機とした同時多発脳出血 Failed Fontanにおける重大な懸念

    赤澤 祐介, 檜垣 高史, 宮田 豊寿, 千阪 俊行, 太田 雅明, 高田 秀実, 東 晴彦, 稲葉 慎二, 井上 勝次, 池田 俊太郎, 江口 真理子, 山口 修

    日本成人先天性心疾患学会雑誌   11 ( 1 )   273 - 273   2022年1月

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    記述言語:日本語   出版者・発行元:日本成人先天性心疾患学会  

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  • 重症肺高血圧を合併したAP windowに対する治療戦略

    赤澤 祐介, 檜垣 高史, 東 晴彦, 河本 敦, 千阪 俊行, 太田 雅明, 高田 秀実, 坂本 裕司, 手島 真弓, 打田 俊司, 井上 勝次, 池田 俊太郎, 江口 真理子, 山口 修

    日本成人先天性心疾患学会雑誌   11 ( 1 )   179 - 179   2022年1月

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    記述言語:日本語   出版者・発行元:日本成人先天性心疾患学会  

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  • 脳膿瘍を契機とした同時多発脳出血 Failed Fontanにおける重大な懸念

    赤澤 祐介, 檜垣 高史, 宮田 豊寿, 千阪 俊行, 太田 雅明, 高田 秀実, 東 晴彦, 稲葉 慎二, 井上 勝次, 池田 俊太郎, 江口 真理子, 山口 修

    日本成人先天性心疾患学会雑誌   11 ( 1 )   273 - 273   2022年1月

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    記述言語:日本語   出版者・発行元:日本成人先天性心疾患学会  

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  • Cardiac amyloidosis screening using a relative apical sparing pattern in patients with left ventricular hypertrophy. 国際誌

    Yasuhisa Nakao, Makoto Saito, Katsuji Inoue, Rieko Higaki, Yuki Yokomoto, Akiyoshi Ogimoto, Moeko Suzuki, Hideo Kawakami, Go Hiasa, Hideki Okayama, Shuntaro Ikeda, Osamu Yamaguchi

    Cardiovascular ultrasound   19 ( 1 )   30 - 30   2021年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    BACKGROUND: Cardiac amyloidosis (CA) mimics left ventricular hypertrophy (LVH). It is treatable, but its prognosis is poor. A simple screening tool for CA would be valuable. CA is more precisely diagnosed with echocardiographic deformation parameters (e.g., relative apical sparing pattern [RASP]) than with conventional parameters. We aimed to 1) investigate incremental benefits of echocardiographic deformation parameters over established parameters for CA screening; 2) determine the resultant risk score for CA screening; and 3) externally validate the score in LVH patients. METHODS: We retrospectively studied 295 consecutive non-ischemic LVH patients who underwent detailed diagnostic tests. CA was diagnosed with biopsy or 99mTc-PYP scintigraphy. The base model comprised age (≥65 years [men], ≥70 years [women]), low voltage on the electrocardiogram, and posterior wall thickness ≥ 14 mm in reference to the literature. The incremental benefit of each binarized echocardiographic parameter over the base model was assessed using receiver operating characteristic curve analysis and comparisons of the area under the curve (AUC). RESULTS: Fifty-four (18%) patients had CA. RASP showed the most incremental benefit for CA screening over the base model. After conducting multiple logistic regression analysis for CA screening using four variables (RASP and base model components), a score was determined (range, 0-4 points). The score demonstrated adequate discrimination ability for CA (AUC = 0.86). This result was confirmed in another validation cohort (178 patients, AUC = 0.88). CONCLUSIONS: We developed a score incorporating RASP for CA screening. This score is potentially useful in the risk stratification and management of LVH patients.

    DOI: 10.1186/s12947-021-00258-x

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  • Utility of Leadless Pacemaker Implantation in Unusual Clinical Scenarios.

    Hiroki Ono, Jun Aono, Shinji Inaba, Haruhiko Higashi, Katsuji Inoue, Shuntaro Ikeda, Toshiki Ochi, Riko Kitazawa, Katsuto Takenaka, Osamu Yamaguchi

    Circulation journal : official journal of the Japanese Circulation Society   85 ( 12 )   2244 - 2244   2021年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1253/circj.CJ-21-0366

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  • Hereditary Transthyretin Cardiac Amyloidosis in Refractory Spinal Canal Stenosis: Genetic and Pathologic Analysis

    Haruhiko Higashi, Katsuji Inoue, Hatsue Ishibashi-Ueda, Osamu Yamaguchi

    Canadian Journal of Cardiology   37 ( 8 )   1289 - 1291   2021年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Elsevier Inc.  

    Transthyretin (TTR) cardiac amyloidosis is a systemic disease caused by amyloid deposits in several systemic organs. The thickening of the yellow ligament because of amyloid deposits results in spinal canal stenosis. This study reports a case of mutant-type TTR cardiac amyloidosis in a patient with recurrent spinal canal stenosis. To our knowledge, this is the first study to report pathologic amyloid involvement in both spinal and cardiac tissues of a patient with hereditary TTR amyloidosis. It is important to be aware of underlying amyloidosis as a cause of spinal canal stenosis, especially regarding refractory diseases in older adults.

    DOI: 10.1016/j.cjca.2021.02.004

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  • Left ventricular longitudinal strain is a major determinant of CT-derived three-dimensional maximum principal strain: comparison with two-dimensional speckle tracking echocardiography.

    Masaki Kinoshita, Yuki Tanabe, Kazuki Yoshida, Akira Kurata, Yusuke Kobayashi, Teruyoshi Uetani, Katsuji Inoue, Kazuhisa Nishimura, Shuntaro Ikeda, Teruhito Mochizuki, Teruhito Kido, Osamu Yamaguchi

    Heart and vessels   37 ( 1 )   31 - 39   2021年7月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Computed tomography (CT)-derived three-dimensional maximum principal strain (MP-strain) can provide incremental value to coronary CT angiography for cardiac dysfunction assessment with high diagnostic performance in patients with myocardial infarction. Global longitudinal strain (GLS) measured using two-dimensional speckle tracking echocardiography (2D-STE) is more sensitive than left ventricular ejection fraction (LVEF) for detecting early myocardial dysfunction. We aimed to compare CT-derived MP-strain with each of 2D-STE-derived strains (i.e., longitudinal, circumferential, and radial strains), and identify the major determinants of CT-derived MP-strain among 2D-STE-derived strains. We studied 51 patients who underwent cardiac CT and echocardiography. CT images were reconstructed at every 5% (0-95%) of the RR interval. A dedicated workstation was used to analyze CT-derived MP-strain on the 16-segment model. We calculated CT-derived global MP-strain with all the 16 segments on a per patient basis. Pearson's test was used to assess correlations between CT-derived MP-strain and STE-strain at global and segmental levels. The intra-class correlation coefficient for interobserver agreement for CT-derived global MP-strain was 0.98 (95% confidence interval 0.96-0.99). The low-CT-derived global MP-strain group (≤ 0.43) had more patients with LV dysfunction than the high-CT-derived global MP-strain group (> 0.43). CT-derived global MP-strain was associated with STE-GLS (r = 0.738, P < 0.001), global circumferential strain (r = 0.646, P < 0.001), and global radial strain (r = 0.432, P = 0.001). In multivariate analysis, STE-GLS had the strongest association to CT-derived global MP-strain among three directional STE-strains and LVEF by echocardiography (standardized coefficient =  - 0.527, P < 0.001). STE-GLS is a major determinant of CT-derived global MP-strain. CT-derived MP-strain may enhance the value of coronary CT angiography by adding functional information to CT-derived LVEF.

    DOI: 10.1007/s00380-021-01901-3

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  • IMPELLAの機械的接触による大動脈弁傷害を病理学的に検討しえた1例

    東 晴彦, 青野 潤, 西村 隆, 浪口 謙治, 坂上 倫久, 倉田 美恵, 井上 勝次, 池田 俊太郎, 泉谷 裕則, 山口 修

    人工臓器   50 ( 1 )   46 - 46   2021年6月

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    記述言語:日本語   出版者・発行元:(一社)日本人工臓器学会  

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  • IMPELLAの機械的接触による大動脈弁傷害を病理学的に検討しえた1例

    東 晴彦, 青野 潤, 西村 隆, 浪口 謙治, 坂上 倫久, 倉田 美恵, 井上 勝次, 池田 俊太郎, 泉谷 裕則, 山口 修

    人工臓器   50 ( 1 )   46 - 46   2021年6月

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    記述言語:日本語   出版者・発行元:(一社)日本人工臓器学会  

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  • Pseudo-electrocardiographic regression of left ventricular hypertrophy in aortic stenosis: concomitant cardiac amyloidosis. 国際誌

    Haruhiko Higashi, Shinji Inaba, Katsuji Inoue, Shuntaro Ikeda, Osamu Yamaguchi

    European heart journal. Cardiovascular Imaging   22 ( 11 )   e155   2021年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1093/ehjci/jeab102

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  • 超高齢社会における心エコー図学の役割 Relative apical sparing patternを含む心アミロイドーシス予測スコアの作成と検証

    齋藤 実, 中尾 恭久, 井上 勝次, 檜垣 里江子, 大木元 明義, 川上 秀生, 日浅 豪, 岡山 英樹, 池田 俊太郎, 山口 修

    超音波医学   48 ( Suppl. )   S209 - S209   2021年4月

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    記述言語:日本語   出版者・発行元:(公社)日本超音波医学会  

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  • 心筋アミロイドーシスにおける左房貯留機能の決定因子となる心基底部の長軸方向ストレインの短縮(Longitudinal Shortening of Cardiac Base as a Determinant of Left Atrial Reservoir Function in Cardiac Amyloidosis)

    井上 勝次, 中尾 恭久, 齋藤 実, 檜垣 里江子, 木下 将城, 東 晴彦, 上谷 晃由, 青野 潤, 永井 啓行, 西村 和久, 池田 俊太郎, 山口 修

    日本循環器学会学術集会抄録集   85回   OJ49 - 4   2021年3月

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    記述言語:英語   出版者・発行元:(一社)日本循環器学会  

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  • A case of hypertrophic obstructive cardiomyopathy in difficulty with computed tomography-guided percutaneous transluminal septal myocardial ablation using Voronoi algorithm(和訳中)

    上谷 晃由, 西村 和久, 赤澤 祐介, 東 晴彦, 稲葉 慎二, 青野 潤, 永井 啓行, 井上 勝次, 池田 俊太郎, 山口 修

    日本心血管インターベンション治療学会抄録集   29回   1216 - 1216   2021年2月

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    記述言語:英語   出版者・発行元:(一社)日本心血管インターベンション治療学会  

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  • Plaque Characterization with Computed Tomography Angiography Based on a Diluted-contrast Injection Protocol.

    Yasuhisa Nakao, Kazuki Yoshida, Shinji Inaba, Yuki Tanabe, Akira Kurata, Teruyoshi Uetani, Teruhito Kido, Katsuji Inoue, Teruhito Mochizuki, Osamu Yamaguchi

    Internal medicine (Tokyo, Japan)   60 ( 23 )   3671 - 3678   2021年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Objective Coronary plaques with low attenuation on computed tomography (CT) angiography may indicate vulnerable plaques. However, plaque CT attenuation is reported to be significantly affected by intracoronary attenuation. Recently, the diluted-contrast injection protocol was established to facilitate more uniform intracoronary attenuation than can be achieved with the generally used body-weight-adjusted protocol. We validated the relationship between low-attenuation plaque on CT and lipid-rich plaque using integrated backscatter-intravascular ultrasound (IB-IVUS) as the standard reference. Methods Plaques were divided into tertiles (T1, T2, and T3) according to the plaque CT attenuation, calculated as the average of five intra-plaque regions of interest, and compared with the plaque characteristics noted on IB-IVUS. Patients Patients who underwent both CT angiography using a diluted-contrast injection protocol and IB-IVUS were retrospectively analyzed. Results Thirty-nine plaques in 32 patients were analyzed by CT angiography and IB-IVUS. The median plaque CT attenuation (Hounsfield units) of each tertile was 30 (T1), 48 (T2), and 68 (T3). Although no significant difference was noted in conventional quantitative IVUS parameters (e.g. plaque burden), the T1 with lowest plaque CT attenuation had the highest percentage lipid area by IB-IVUS [75.1% (T1), 57.8% (T2), and 50.8% (T3), respectively, p<0.01]. Furthermore, the plaque CT attenuation had a significant negative correlation with the percentage lipid area (r=-0.59, p<0.01). Conclusion CT angiography-based plaque characterization using a diluted-contrast injection protocol may aid in the quantitative detection of lipid-rich plaque.

    DOI: 10.2169/internalmedicine.6683-20

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  • Correction to: Review of the efforts of the Japanese Society of Echocardiography for coronavirus disease 2019 (COVID-19) during the initial outbreak in Japan (Journal of Echocardiography, (2020), 18, 4, (226-233), 10.1007/s12574-020-00487-5)

    Yoshihiro Seo, Masao Daimon, Hirotsugu Yamada, Nobuyuki Kagiyama, Mitsuhiko Ohta, Chisato Izumi, Kazuhiro Yamamoto, Satoshi Nakatani, Yasushi Sakata, Hiroyuki Toide, Kazumi Akasaka, Katsuji Inoue, Tetsuari Ohnishi, Kaoru Dohi, Tsuyoshi Yoshimuta, Nozomi Watanabe, Toshimi Koitabashi, Takako Iino, Kaoru Komuro, Atsushi Kobayashi, Akihiro Hayashida, Naoko Mizukami, Kumiko Hirata, Yasuaki Wada, Atsushi Kotani, Kiyohiro Takigiku, Makoto Miyake, Hiroki Okaniwa, Yutaka Hirano, Mitsushige Murata, Kengo Suzuki

    Journal of Echocardiography   18 ( 4 )   234   2020年12月

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    掲載種別:研究論文(学術雑誌)  

    In the original publication of the article, the text citations of the Figs. 4-1, 4-2 and 5 should be Figs. 4, 5 and 6.

    DOI: 10.1007/s12574-020-00494-6

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  • Usefulness of contrast computed tomography for diagnosing left ventricular thrombus before impella insertion.

    Yasuhisa Nakao, Jun Aono, Kenji Namiguchi, Takashi Nishimura, Hironori Izutani, Haruhiko Higashi, Shinji Inaba, Kazuhisa Nishimura, Katsuji Inoue, Shuntaro Ikeda, Osamu Yamaguchi

    Journal of cardiology cases   22 ( 6 )   291 - 293   2020年12月

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    記述言語:英語  

    The Impella (Abiomed, Danvers, MA, USA) is a novel percutaneous heart pump device for left ventricular (LV) assistance; however, LV thrombus is a notable contraindication for this device. Contrast computed tomography assessment is useful for detecting LV thrombus and preventing thromboembolism in patients recommended for Impella use. <Learning objective: The Impella (Abiomed, Danvers, MA, USA) is a heart pump device which aspirates blood from a left ventricular (LV) cavity and ejects it into an ascending aorta. Therefore, LV thrombus should be explored before the Impella insertion to prevent systemic embolism. Generally, echocardiography is the first choice to detect LV thrombus. Given limited diagnostic sensitivity for detecting LV thrombus in echocardiography, contrast computed tomography might be a useful strategy for the patient targeting Impella insertion.>.

    DOI: 10.1016/j.jccase.2020.07.016

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  • Characteristics of the left ventricular three-dimensional maximum principal strain using cardiac computed tomography: reference values from subjects with normal cardiac function. 国際誌

    Kazuki Yoshida, Yuki Tanabe, Teruhito Kido, Akira Kurata, Daichi Uraoka, Masaki Kinoshita, Teruyoshi Uetani, Kazuhisa Nishimura, Katsuji Inoue, Shuntaro Ikeda, Osamu Yamaguchi, Teruhito Mochizuki

    European radiology   30 ( 11 )   6109 - 6117   2020年11月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    OBJECTIVES: This study evaluated the characteristics of left ventricular maximum principal strain (LV-MPS) using cardiac CT in subjects with normal LV function. METHODS: Of 973 subjects who underwent retrospective electrocardiogram-gated cardiac CT using a third-generation dual-source CT without beta-blocker administration, 31 subjects with preserved LV ejection fraction ≥ 55% assessed by echocardiography without coronary artery stenosis and cardiac pathology were retrospectively identified. CT images were reconstructed every 5% (0-95%) of the RR interval. LV-MPS and the time to peak (TTP) were analyzed using the 16-segment model and compared among three levels (base, mid, and apex) and among four regions (anterior, septum, inferior, and lateral) using the Steel-Dwass test. The intra- and inter-observer reproducibilities for LV-MPS were calculated using intraclass correlation coefficients (ICCs). RESULTS: The intra- and inter-observer ICCs (95% confidence interval) for peak LV-MPS were 0.96 (0.94-0.97) and 0.94 (0.92-0.96), respectively. The global peak LV-MPS (median, inter-quantile range) was 0.59 (0.55-0.72). The regional LV-MPS significantly increased in the order of the basal (0.54, 0.49-0.59), mid-LV (0.57, 0.53-0.65), and apex (0.68, 0.60-0.84) (p < 0.05, in each), and was significantly higher in the lateral wall (0.66, 0.60-0.77), while that in the septal region (0.47, 0.44-0.54) was the lowest among the four LV regions (all p < 0.05). No significant difference in TTP was seen among the myocardial levels and regions. CONCLUSION: CT-derived LV-MPS is reproducible and quantitatively represents synchronized myocardial contraction with heterogeneous values in subjects with normal LV function. KEY POINTS: • CT-derived left ventricular maximum principal strain analysis allows highly reproducible quantitative assessments of left ventricular myocardial contraction. • In subjects with normal cardiac function, the peak value of CT-derived left ventricular maximum principal strain is the highest in the apical level and in the lateral wall and the lowest in the septum. • The regional peak left ventricular maximum principal strain shows intra-ventricular heterogeneity on a per-patient basis, but myocardial contraction is globally synchronized in subjects with normal cardiac function seen on cardiac CT.

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  • 心アミロイドーシス患者におけるrelative apical sparingパターンの臨床的意義

    齋藤 実, 河内 好子, 檜垣 里江子, 中尾 恭久, 大木元 明義, 川上 秀生, 岡山 英樹, 井上 勝次, 池田 俊太郎, 山口 修

    超音波医学   47 ( Suppl. )   S203 - S203   2020年11月

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    記述言語:日本語   出版者・発行元:(公社)日本超音波医学会  

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  • Features and clinical impact of extra-cardiac lesions with 18F-fluorodeoxyglucose positron emission tomography in patients with suspected cardiac sarcoidosis. 国際誌

    Haruhiko Higashi, Shinji Inaba, Chiharuko Iio, Katsuji Inoue, Akiyoshi Ogimoto, Masao Miyagawa, Teruhito Mochizuki, Shuntaro Ikeda, Osamu Yamaguchi

    International journal of cardiology. Heart & vasculature   30   100587 - 100587   2020年10月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Background: Sarcoidosis is a systemic inflammatory disorder and can often affect any other organs beyond the heart. Whole-body 18F-fluorodeoxyglucose positron emission tomography (FDG-PET) is used to detect not only cardiac but also extra-cardiac involvement of sarcoidosis. However, the features and clinical impact of extra-cardiac lesions have not yet been fully elucidated. Therefore, this study aimed to clarify these using FDG-PET. Methods and results: We enrolled 120 consecutive patients with abnormal findings clinically suggesting cardiac sarcoidosis who underwent whole-body FDG-PET. In this study, a patient with suspected cardiac sarcoidosis was defined as one having both clinically suspected findings and FDG-PET positive cardiac uptake. Subsequently, a total of 36 patients with suspected cardiac sarcoidosis were found and analyzed. Extra-cardiac involvement was detected in 35 lesions of 14 patients (39% per patient). In particular, the extra-cardiac lesions were widely distributed throughout the body, and mediastinal/hilar lymph node involvement was most commonly observed. In most of the patients (93% per patient, 13/14), the extra-cardiac lesions were localized in the regions that were considered more accessible with less risk of complication compared with endomyocardial biopsy (EMB). Based on the FDG-PET findings, 8 patients underwent extra-cardiac biopsy without complication, and its diagnostic sensitivity for histological sarcoidosis was high (75%, 6/8). Moreover, FDG-PET-guided extra-cardiac biopsy could confirm histological sarcoidosis in 4 lesions that EMB failed to prove. Conclusions: Extra-cardiac involvement in patients with suspected cardiac sarcoidosis was relatively high. FDG-PET-guided extra-cardiac biopsy may be safe and useful for the imaging based diagnosis of cardiac sarcoidosis.

    DOI: 10.1016/j.ijcha.2020.100587

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  • IMPELLA補助中に生じる出血性合併症の発生要因に関する検討

    薦田 宗則, 西村 隆, 坂本 裕司, 浪口 謙治, 太田 教隆, 黒部 裕嗣, 打田 俊司, 八杉 巧, 三好 徹, 稲葉 慎二, 東 晴彦, 上谷 晃由, 青野 潤, 西村 和久, 井上 勝次, 鈴木 純, 池田 俊太郎, 山口 修, 泉谷 裕則

    人工臓器   49 ( 2 )   S - 128   2020年10月

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    記述言語:日本語   出版者・発行元:(一社)日本人工臓器学会  

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  • Atrial tachycardia with multiple reconductions across the surgical incision. 国際誌

    Takayuki Nagai, Hiroshi Kawakami, Yasuhiro Sasaki, Akira Fujii, Katsuji Inoue, Shuntaro Ikeda, Osamu Yamaguchi

    Journal of cardiovascular electrophysiology   31 ( 9 )   2526 - 2529   2020年9月

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    記述言語:英語  

    Incisional atrial tachycardia (AT) with multiple penetrating points on one surgical incision has not been reported yet. We present a case of incisional AT following mitral valve annuloplasty with a superior transseptal approach, in which two reconduction sites were parts of the reentrant circuit. Radiofrequency ablation at the reconduction site successfully terminated the tachycardia. A total of four penetrating points were found on the incision line, and radiofrequency ablation at these sites was completed. Detailed mapping of possible reconduction sites along the incision line should be performed to avoid further instances of AT following open heart surgery.

    DOI: 10.1111/jce.14690

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  • Prognostic assessment of relative apical sparing pattern of longitudinal strain for severe aortic valve stenosis. 国際誌

    Makoto Saito, Misaki Imai, Daisuke Wake, Rieko Higaki, Yasuhisa Nakao, Hiroe Morioka, Takumi Sumimoto, Katsuji Inoue

    International journal of cardiology. Heart & vasculature   29   100551 - 100551   2020年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    BACKGROUNDS: The relative apical sparing pattern (RASP) of left ventricular (LV) longitudinal strain (LS) is frequently associated with cardiac amyloidosis. Elderly patients with aortic valve stenosis (AS) complicated by transthyretin amyloid cardiomyopathy have poor prognosis. Furthermore, deteriorated basal LS in AS patients has been reported to be associated with adverse outcome. We investigated the association between RASP and outcomes in patients with severe AS. METHODS: We retrospectively studied 156 consecutive patients with severe AS and preserved LV ejection fraction. RASP was assessed by both of semi-quantitative (sRASP) and quantitative (qRASP) methods. sRASP was defined as a deterioration of LS (≥-10%) in ≥ 5 (of 6) basal segments, relative to preserved LS (<-15%) in at least 1 apical segment. qRASP was calculated using the following formula: average apical LS/(average basal LS + average mid-ventricle LS); qRASP ≥ 1 was defined as positive. Patients were followed up to determine outcomes, which included sudden cardiac death or unexpected admission due to heart failure, over a median of 1.9 years. RESULTS: sRASP and qRASP were assessed in all patients, but 24 and 42 patients fulfilled the criteria for sRASP and qRASP, respectively. Both assessments were significantly associated with outcomes (n = 44; 28%). Furthermore, sRASP was significantly associated with outcome after adjusting for EuroSCORE, NYHA ≥ II, or global longitudinal strain. A model based on these covariates for predicting outcomes significantly improved by adding sRASP. CONCLUSION: RASP is observed in some patients with severe AS and provides additive prognostic information over conventional parameters.

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  • Reconstruction of Apical 2-Chamber View From Apical 4- and Long-Axis Views on Echocardiogram Using Machine Learning - Pilot Study With Deep Generative Modeling.

    Akinori Higaki, Katsuji Inoue, Masaki Kinoshita, Shuntaro Ikeda, Osamu Yamaguchi

    Circulation reports   1 ( 4 )   197 - 197   2019年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1253/circrep.CR-19-0011

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  • 当院における成人動脈管開存症に対する経カテーテル的閉鎖術の検討(Transcatheter closure for patent ductus arteriosus in adults at our hospital)

    赤澤 祐介, 鈴木 萌子, 中尾 恭久, 東 晴彦, 佐々木 康浩, 藤井 昭, 上谷 晃由, 青野 潤, 永井 啓行, 西村 和久, 井上 勝次, 池田 俊太郎, 宮田 豊寿, 森谷 友造, 千阪 俊行, 高田 秀実, 檜垣 高史, 石井 榮一, 山口 修

    日本成人先天性心疾患学会雑誌   8 ( 1 )   113 - 113   2019年1月

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    記述言語:英語   出版者・発行元:(一社)日本成人先天性心疾患学会  

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  • 上大静脈症候群に対する自己拡張型ステント留置術(Self-expandable stent placement for treatment of superior vena cava syndrome)

    赤澤 祐介, 鈴木 萌子, 中尾 恭久, 東 晴彦, 佐々木 康浩, 藤井 昭, 上谷 晃由, 青野 潤, 永井 啓行, 西村 和久, 井上 勝次, 池田 俊太郎, 宮田 豊寿, 森谷 友造, 千阪 俊行, 高田 秀実, 打田 俊司, 檜垣 高史, 石井 榮一, 山口 修

    日本成人先天性心疾患学会雑誌   8 ( 1 )   155 - 155   2019年1月

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    記述言語:英語   出版者・発行元:(一社)日本成人先天性心疾患学会  

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  • Intravascular Ultrasound-Derived Virtual Fractional Flow Reserve for the Assessment of Myocardial Ischemia.

    Fumiyasu Seike, Teruyoshi Uetani, Kazuhisa Nishimura, Hiroshi Kawakami, Haruhiko Higashi, Akira Fujii, Jun Aono, Takayuki Nagai, Katsuji Inoue, Jun Suzuki, Shinji Inaba, Takafumi Okura, Kazunori Yasuda, Jitsuo Higaki, Shuntaro Ikeda

    Circulation journal : official journal of the Japanese Circulation Society   82 ( 3 )   815 - 823   2018年2月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    BACKGROUND: Fractional flow reserve (FFR) is widely used for the assessment of myocardial ischemia. Intravascular ultrasound (IVUS) is an intracoronary imaging method that provides information about lumen and vessel morphology. Previous studies on the expanded use of IVUS to identify functional ischemia have noted an association between anatomy and physiology, but IVUS-derived minimum lumen area (MLA) has a weak-moderate correlation with myocardial ischemia compared with FFR. We developed a method to calculate FFR using IVUS-derived anatomical information for the assessment of myocardial ischemia. The aims of this study were to investigate the relationship between wire-based FFR and IVUS-derived FFR (IVUS-FFR) and to compare the usefulness of IVUS-FFR and IVUS-derived MLA for functional assessment.Methods and Results:We retrospectively analyzed 50 lesions in 48 patients with coronary stenosis who underwent IVUS and FFR simultaneously. IVUS-FFR was calculated using our original algorithm and fluid dynamics. Mean percent diameter stenosis determined on quantitative coronary angiography and on FFR was 56.4±10.7 and 0.69±0.08, respectively. IVUS-FFR had a stronger linear correlation with FFR (R=0.78, P<0.001; root mean square error, 0.057 FFR units) than with IVUS-derived MLA (R=0.43, P=0.002). CONCLUSIONS: IVUS-FFR may be a more valuable method to identify myocardial ischemia, compared with IVUS-derived MLA.

    DOI: 10.1253/circj.CJ-17-1042

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  • Intracoronary Optical Coherence Tomography-Derived Virtual Fractional Flow Reserve for the Assessment of Coronary Artery Disease 査読 国際誌

    Fumiyasu Seike, Teruyoshi Uetani, Kazuhisa Nishimura, Hiroshi Kawakami, Haruhiko Higashi, Jun Aono, Takayuki Nagai, Katsuji Inoue, Jun Suzuki, Hideo Kawakami, Takafumi Okura, Kazunori Yasuda, Jitsuo Higaki, Shuntaro Ikeda

    AMERICAN JOURNAL OF CARDIOLOGY   120 ( 10 )   1772 - 1779   2017年11月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:EXCERPTA MEDICA INC-ELSEVIER SCIENCE INC  

    Fractional flow reserve (FFR) is widely used for the assessment of myocardial ischemia. Optical coherence tomography (OCT) provides accurate visualization of coronary artery morphology. The aim of this study was to investigate the relation between FFR and OCT-derived FFR. We retrospectively analyzed 31 lesions (25 left anterior descending arteries, 2 left circumflex arteries, and 4 right coronary arteries) in 31 patients with moderate-to severe coronary stenosis, who underwent OCT and FFR measurements simultaneously. OCT-derived FFR was calculated by the original algorithm, which was calculated using the following equation based on fluid dynamics: Delta P = FV + SV2, where V is the flow velocity, F is the coefficient of pressure loss because of viscous friction (Poiseuille resistance), and S is the coefficient of local pressure loss because of abrupt enhancement (flow separation). Mean values of % diameter stenosis by quantitative coronary angiography and FFR were 55.2 +/- 14.0% and 0.70 +/- 0.14, respectively. OCT-derived FFR showed a stronger linear correlation with FFR measurements (r = 0.89, p &lt;0.001; root mean square error = 0.062 FFR units) than quantitative coronary angiography % diameter stenosis (r = 0.65, p &lt;0.001), OCT measurements of minimum lumen area (r = 0.68, p &lt;0.001), and % area stenosis (r = 0.70, p &lt;0.001). OCT-derived FFR has the potential to become an alternative method for the assessment of functional myocardial ischemia, and may elucidate the relation between coronary morphology and FFR. (C) 2017 Elsevier Inc. All rights reserved.

    DOI: 10.1016/j.amjcard.2017.07.083

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  • Clinical significance of atrial high-rate episodes for thromboembolic events in Japanese population. 国際誌

    Hiroshi Kawakami, Takayuki Nagai, Makoto Saito, Shinji Inaba, Fumiyasu Seike, Kazuhisa Nishimura, Katsuji Inoue, Takafumi Okura, Takumi Sumimoto, Shigeki Uemura, Jitsuo Higaki, Shuntaro Ikeda

    Heart Asia   9 ( 2 )   e010954   2017年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Objective: The clinical significance of atrial high-rate episodes (AHREs) detected by cardiac devices among patients with implantable pacemakers has recently emerged. However, the relationship between AHREs and ischaemic stroke and systemic embolism (SE) is not well understood in the Japanese population. Methods: This study included 343 patients with pacemakers capable of continuous atrial rhythm monitoring (167 males; mean age, 80±7 years). Atrial tachyarrhythmia detection was programmed to the nominal setting of each device, and AHRE was defined as any episode of sustained atrial tachyarrhythmia lasting for more than 6 min. Thromboembolic risk was defined based on the CHADS2 score. Results: During the follow-up period (52±30 months), 165 (48%) patients had at least one episode of AHREs, and 19 (6%) patients experienced stroke/SE. Among patients who experienced stroke/SE, 14 had AHREs before the stroke/SE. AHREs were significantly associated with stroke/SE (HR 2.87; 95% CI 1.10 to 8.90; p=0.03). Subgroup analysis conducted to investigate the impact of the CHADS2 score severity on stroke/SE revealed that AHREs were not associated with stroke/SE in patients with low or intermediate thromboembolic risk (CHADS2 score 0-2; n=217). In contrast, among patients with high thromboembolic risk (CHADS2 score>2; n=126), there was a significant association between AHREs and the incidence of stroke/SE (HR 3.73; 95% CI 1.06 to 13.1; p=0.04). Conclusion: AHREs detected by pacemaker were associated with ischaemic stroke/SE in the Japanese population. However, this association was observed only in the high thromboembolic risk group.

    DOI: 10.1136/heartasia-2017-010954

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  • Apnea-hypopnea index as a predictor of atrial fibrillation recurrence following initial pulmonary vein isolation: usefulness of type-3 portable monitor for sleep-disordered breathing 査読

    Hiroshi Kawakami, Takayuki Nagai, Akira Fujii, Teruyoshi Uetani, Kazuhisa Nishimura, Katsuji Inoue, Jun Suzuki, Yasunori Oka, Takafumi Okura, Jitsuo Higaki, Akiyoshi Ogimoto, Shuntaro Ikeda

    JOURNAL OF INTERVENTIONAL CARDIAC ELECTROPHYSIOLOGY   47 ( 2 )   237 - 244   2016年11月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:SPRINGER  

    AHI measured using type-3 PM is a useful predictor of outcome following initial PVI in patients with paroxysmal AF.

    DOI: 10.1007/s10840-016-0148-z

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  • Correlation Between Quantitative Angiography-Derived Translesional Pressure and Fractional Flow Reserve 査読

    Fumiyasu Seike, Teruyoshi Uetani, Kazuhisa Nishimura, Chiharuko Iio, Hiroshi Kawakami, Kaori Fujimoto, Haruhiko Higashi, Tamami Kono, Jun Aono, Takayuki Nagai, Katsuji Inoue, Jun Suzuki, Akiyoshi Ogimoto, Takafumi Okura, Kazunori Yasuda, Jitsuo Higaki, Shuntaro Ikeda

    AMERICAN JOURNAL OF CARDIOLOGY   118 ( 8 )   1158 - 1163   2016年10月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:EXCERPTA MEDICA INC-ELSEVIER SCIENCE INC  

    Fractional flow reserve (FFR) is widely used for the assessment of myocardial ischemia. However, it has the disadvantage of cost and invasive complication risks. We investigated the usefulness of quantitative coronary angiography derived translesional pressure (QCA-TP) for predicting functional myocardial ischemia, using FFR as the gold standard. We retrospectively analyzed 152 coronary narrowings (98 left anterior descending arteries, 28 left circumflex arteries, and 26 right) in 132 patients with mild-severe coronary stenosis who underwent coronary angiography and FFR measurements simultaneously. QCA-TP was calculated using software implemented in the QCA software. Coronary morphology was calculated using both densitometry and lumen edges. Functional myocardial ischemia was defined as an FFR of 0.8 or less. The mean values of diameter stenosis by QCA and FFR were 48.9% +/- 14.9 and 0.76 +/- 0.14, respectively. QCA-TP was significantly correlated with FFR (r = 0.76, p &lt;0.01). The cut-off values of QCA-TP for predicting functional myocardial ischemia based on FFR were 72.8 mm Hg for the left, anterior descending arteries (accuracy, 86.7%; area under the curve [AUC], 0.93), 60.5 mm Hg for the left circumflex arteries (accuracy, 89.3%; AUC, 0.88), and 64.4 mm Hg for the right (accuracy, 88.5%; AUC, 0.94). Therefore, our data suggest that QCA-TP can predict myocardial ischemia with high diagnostic accuracy. (C) 2016 Elsevier Inc. All rights reserved.

    DOI: 10.1016/j.amjcard.2016.07.026

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  • Aortic prosthetic graft infection detected by (18)F-fluorodeoxyglucose positron emission tomography/computed tomography. 国際誌

    Tamami Kono, Akiyoshi Ogimoto, Chiharuko Iio, Kaori Fujimoto, Akira Fujii, Teruyoshi Uetani, Takayuki Nagai, Kazuhisa Nishimura, Katsuji Inoue, Jun Suzuki, Go Hiasa, Hideki Okayama, Takafumi Okura, Masao Miyagawa, Teruhito Mochizuki, Hironori Izutani, Jitsuo Higaki

    International journal of cardiology   203   972 - 4   2016年1月

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  • Enormous Pedunculated Vegetation Originating in the Left Ventricular Apex in a Patient with Infective Endocarditis

    Murata Azusa, Inoue Kenji, Maruyama Sonomi, Iguchi Shigekazu, Sugita Manabu, Hiki Makoto, Okazaki Shinya, Okai Iwao, Fujiwara Yasumasa, Sumiyoshi Masataka, Yamamoto Taira, Amano Atsushi, Daimon Masao, Daida Hiroyuki

    Internal Medicine   55 ( 20 )   2971 - 2973   2016年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:一般社団法人 日本内科学会  

    <p>A healthy teenage Japanese girl was admitted to our hospital after experiencing out-of-hospital cardiac arrest. She had attempted to commit suicide by taking 4,950 mg of disopyramide and 12 mg of flunitrazepam. Mechanical cardiopulmonary support was started with percutaneous cannulation of the femoral vessels. Several days later, a blood culture tested positive for <i>Staphylococcus aureus</i>. Transthoracic echocardiography showed a large mobile and solid mass attached to the apical part of the left ventricle. To the best of our knowledge, the anatomical location of a pedunculated mass originating from the apex is a rare condition. </p>

    DOI: 10.2169/internalmedicine.55.7043

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  • Identifying the true origin of sustained monomorphic ventricular tachycardia associated with dilated-phase hypertrophic cardiomyopathy: A case of successful catheter ablation. 査読

    Hiroshi Kawakami, Takayuki Nagai, Akira Fujii, Teruyoshi Uetani, Kazuhisa Nishimura, Katsuji Inoue, Jun Suzuki, Kazuhiro Satomi, Takafumi Okura, Jitsuo Higaki, Akiyoshi Ogimoto

    Journal of arrhythmia   31 ( 6 )   406 - 9   2015年12月

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    記述言語:英語  

    This case report describes sustained monomorphic ventricular tachycardia (VT) caused by a large epicardial scar, related to dilated-phase hypertrophic cardiomyopathy mimicking VT originating from the apical septum. VT resolved with epicardial catheter ablation. The exit of the VT circuit suggested that a 12-lead electrocardiogram can be remote with respect to the critical isthmus in this case. In patients with structural heart disease, it is difficult to identify the VT reentrant circuit by surface electrocardiography, which shows only the exit site. VT originating in the epicardium should be considered, even if the suspected origin is another ventricular site.

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  • Association Between Genetic Variation in the <i>SCN10A</i> Gene and Cardiac Conduction Abnormalities in Patients With Hypertrophic Cardiomyopathy

    Iio Chiharuko, Ogimoto Akiyoshi, Nagai Takayuki, Suzuki Jun, Inoue Katsuji, Nishimura Kazuhisa, Uetani Teruyoshi, Okayama Hideki, Okura Takafumi, Shigematsu Yuji, Tabara Yasuharu, Kohara Katsuhiko, Miki Tetsuro, Hamada Mareomi, Higaki Jitsuo

    International Heart Journal   2015年

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    記述言語:英語   出版者・発行元:International Heart Journal Association  

    Arrhythmias are associated with reduced quality of life and poor prognosis in patients with hypertrophic cardiomyopathy (HCM). Recent genome-wide association studies revealed that a nonsynonymous single nucleotide polymorphism, rs6795970, in the <i>SCN10A</i> gene was associated with the PR interval. We examined whether the PR prolonging allele (A allele) in the <i>SCN10A</i> gene may be associated with cardiac conduction abnormalities in HCM patients.<br>We genotyped the polymorphism in 149 HCM patients. Conduction abnormalities were defined as first-degree heart block, bundle-branch block, and bifascicular heart block. Patients were divided into two groups: group A consisted of 122 patients (82%) without a conduction abnormality; and group B consisted of 27 patients (18%) with one or more cardiac conduction abnormalities. The frequency distribution of the <i>SCN10A</i> genotypes (G/G, G/A, and A/A) among the patients with HCM was 71%, 26%, and 3%, respectively. A cardiac conduction abnormality was documented in 9% with G/G and 40% with G/A or A/A. There was a significant difference in the genotype distribution between the two groups (<i>P</i> = 0.0002). In the dominant A allele model, there was a significant difference in genotypes between the two groups (<i>P</i> < 0.0001). In addition, the A allele remained significant after adjusting for other covariates in a multivariate model (odds ratio = 6.30 [95% confidence interval: 2.24 to 19.09], <i>P</i> = 0.0005).<br>The rs6795970 in the <i>SCN10A</i> gene, which is reported to carry a high risk of heart block, might be associated with cardiac conduction abnormalities in HCM patients.

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  • 草刈り作業による機械的刺激によってデバイス感染を合併したBrugada症候群の1例

    櫃本 竜郎, 西村 和久, 上谷 晃由, 永井 啓行, 井上 勝次, 鈴木 純, 大蔵 隆文, 檜垣 實男, 大木元 明義

    心臓   47 ( 2 )   166 - 171   2015年

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    記述言語:日本語   出版者・発行元:公益財団法人 日本心臓財団  

    症例は75歳, 男性. 失神発作を伴うBrugada症候群に対して2012年9月に植込み型除細動器 (implantable cardioverter defibrillator ; ICD) 移植術を施行した. ICD植込み8カ月後に草刈り機を使用し, 約5時間の草刈り作業を行った. 植込み部位に軽い違和感があったが放置し, 数日後挫創ができていることに気付き近医を受診した. 創部は徐々に拡大し, 数日で創部が開放したためデバイス感染が強く疑われ精査加療目的で当院に入院した. 左前胸部の創部に膿瘍を形成しており, 鑷子で創部を観察すると容易にICD本体が外部と開通していたためデバイス感染と診断した. 入院第2病日にICDを全抜去し, 抗生剤による厳重な感染コントロールを行った後, 反対側からICD再植込み術を施行した. デバイス感染予防には草刈り作業などの物理的刺激の回避も重要と考えられ, デバイス感染の診断・治療・管理についても文献的考察を加えて報告する.

    DOI: 10.11281/shinzo.47.166

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    その他リンク: http://search.jamas.or.jp/link/ui/2015217613

  • Cardiac magnetic resonance imaging for assessment of steroid therapy in a patient with cardiac sarcoidosis and a magnetic resonance-conditional pacemaker. 国際誌

    Tamami Kono, Akiyoshi Ogimoto, Makoto Saito, Kaori Fujimoto, Akira Fujii, Teruyoshi Uetani, Takayuki Nagai, Kazuhisa Nishimura, Katsuji Inoue, Jun Suzuki, Takafumi Okura, Tomoyuki Kido, Masao Miyagawa, Teruhito Mochizuki, Jitsuo Higaki

    International journal of cardiology   176 ( 3 )   e89-91   2014年10月

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  • 心室中隔中部に憩室様の菲薄化をきたした心サルコイドーシスの1例

    村上 千佳, 永井 啓行, 飯尾 千春子, 藤井 昭, 西村 和久, 井上 勝次, 鈴木 純, 宮川 正男, 望月 輝一, 檜垣 實男, 大木元 明義

    心臓   45 ( 8 )   1007 - 1012   2013年8月

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    記述言語:日本語   出版者・発行元:(公財)日本心臓財団  

    症例は73歳、女性。2005年に検診の胸部X線検査で胸部異常陰影を指摘され、気管支鏡下肺生検で肺サルコイドーシスと確定診断された。以降、他科にて経過観察中であったが、2011年に施行した心エコー図検査で心室中隔中部の壁菲薄化を認め、心サルコイドーシスが疑われたため、当科に入院した。冠動脈造影では異常を認めなかったが、心筋血流シンチグラムにて菲薄化部位に一致して灌流異常を認め、ヘパリン負荷下の18F-FDG-PETでは同部位を中心に心臓への異常集積を認めた。心サルコイドーシスの可能性が高いと考えられたため、ステロイド加療を開始した。心サルコイドーシスの特徴的形態としては心室中隔基部の壁菲薄化があげられているが、現在までに心室中隔中部の壁菲薄化をきたした報告はない。心サルコイドーシスの表現型として心室中隔中部の菲薄化・憩室があることを念頭におき、各種モダリティでの精査を行い、早期に診断することが重要と考えられたため、文献的考察を加え報告する。(著者抄録)

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  • スペックルトラッキング法を用いた左心房機能評価の有用性と限界

    鹿野 由香理, 井上 勝次, 飯尾 千春子, 藤井 昭, 西村 和久, 永井 啓行, 鈴木 純, 大木 元明義, 檜垣 實男, 宮崎 真紀, 高須 賀康宣, 西宮 達也

    超音波検査技術抄録集   38   S167   2013年

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    記述言語:日本語   出版者・発行元:一般社団法人 日本超音波検査学会  

    DOI: 10.11272/jssabst.38.0_S167

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  • Acute Effects of Adaptive Servo Ventilation on Hemodynamics, Coronary Flow, and Flow Reserve in a Patient With Idiopathic Dilated Cardiomyopathy 査読

    Haruhiko Higashi, Makoto Saito, Hideki Okayama, Toyofumi Yoshii, Go Hiasa, Kazuhisa Nishimura, Katsuji Inoue, Akiyoshi Ogimoto, Jitsuo Higaki

    CANADIAN JOURNAL OF CARDIOLOGY   28 ( 5 )   611.e11 - 3   2012年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:ELSEVIER SCIENCE INC  

    Adaptive servo ventilation (ASV) is reported to be effective for the treatment of heart failure. We treated a patient with idiopathic dilated cardiomyopathy using ASV and assessed the effects on hemodynamics, coronary flow, and flow reserve before and after ASV therapy. This case suggests that ASV might decrease myocardial oxygen demand, which was represented by the decreased resting coronary flow velocity (the improvement of coronary flow velocity reserve) on ASV.

    DOI: 10.1016/j.cjca.2012.02.016

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  • Impact of type 2 diabetes on serial changes in tissue characteristics of coronary plaques: an integrated backscatter intravascular ultrasound analysis. 国際誌

    Shinji Inaba, Hideki Okayama, Jun-ichi Funada, Haruhiko Higashi, Makoto Saito, Toyofumi Yoshii, Go Hiasa, Takumi Sumimoto, Yasunori Takata, Kazuhisa Nishimura, Katsuji Inoue, Akiyoshi Ogimoto, Jitsuo Higaki

    European heart journal. Cardiovascular Imaging   13 ( 9 )   717 - 23   2012年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    AIMS: Several studies have demonstrated that type 2 diabetes mellitus (T2DM) is associated with accelerated atherosclerosis, which results in an increased risk of coronary vascular events. However, serial changes in plaque characteristics have not been reported in vivo. We evaluated the progression of coronary atherosclerosis in patients with T2DM using an integrated backscatter intravascular ultrasound (IB-IVUS) examination. METHODS AND RESULTS: Forty-two T2DM and 48 non-diabetic patients who underwent percutaneous coronary intervention were enrolled in the study. Non-culprit 20-mm length coronary lesions with mild-to-moderate stenosis were measured using a 40-MHz (motorized pullback of 0.5 mm/s) IVUS catheter. IVUS examinations were performed on one target lesion in each patient. Six months later, a follow-up IVUS examination was repeated in the same coronary segment imaged at the baseline examination. T2DM patients demonstrated a greater total plaque volume (TPV; 139 ± 53 vs. 114 ± 45 mm(3), P = 0.02) and total lipid volume (TLV; 67 ± 26 vs. 55 ± 30 mm(3), P = 0.039) at the baseline examination. The progression of TPV (8.6 ± 15.4 vs. -2.2 ± 16.0%, P < 0.01) and TLV (10.8 ± 28.8 vs. -2.5 ± 20.0%, P < 0.05) from the baseline was observed in T2DM patients, but not in non-diabetic patients. The increase in TLV was blunted in T2DM patients who achieved HbA1c levels of <6.5%. CONCLUSION: Accelerated plaque progression with an increase in the lipid-rich component of non-culprit plaques was observed in T2DM, despite the use of standard medical treatment. Better glycaemic control ameliorated the worsening of plaque characteristics in T2DM.

    DOI: 10.1093/ehjci/jes033

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  • Impact of Synergistic Polymorphisms in Adrenergic Receptor-Related Genes and Cardiovascular Events in Patients With Dilated Cardiomyopathy

    OGIMOTO Akiyoshi, OKAYAMA Hideki, NAGAI Takayuki, SUZUKI Jun, INOUE Katsuji, NISHIMURA Kazuhisa, SHIGEMATSU Yuji, TABARA Yasuharu, MIKI Tetsuro, HIGAKI Jitsuo

    Circulation journal : official journal of the Japanese Circulation Society   76 ( 8 )   2003 - 2008   2012年7月

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    記述言語:英語   出版者・発行元:一般社団法人 日本循環器学会  

    Background: Sustained cardiac adrenergic stimulation has been implicated in the progression of cardiovascular events in patients with dilated cardiomyopathy (DCM). Our group hypothesized that a combination of polymorphisms that result in increased synaptic norepinephrine release and enhanced receptor function would predispose patients with DCM to cardiovascular events. The effect of polymorphisms in adrenergic receptor-related genes on cardiovascular event-free survival in patients with idiopathic DCM was evaluated. Methods and Results: Genotyping at 3 loci (ADRB1 Ser49Gly and Arg389Gly, and NET T-182C) was performed in 83 patients with DCM. Patients were followed prospectively to the endpoint of cardiovascular events (mean follow-up, 45 months). Cardiovascular events were defined as cardiac death and emergent hospitalization as a result of congestive heart failure, arrhythmia, and cerebrovascular events. Analyses were conducted based on the number of predicted risk genotypes a patient carried. The ADRB1 Ser49 allele carrier, ADRB1 Arg389 allele carrier, and NET-182CC genotype were defined as the predicted risk genotypes. Cardiovascular event-free survival was compared based on the number of predicted risk genotypes. Cardiovascular event-free survival was significantly better in patients with fewer than 3 predicted risk genotypes than in those with 3 predicted risk genotypes. Conclusions: Genotyping at these 3 loci might be a useful approach for identification of patients with DCM at risk for cardiovascular events.  (Circ J 2012; 76: 2003–2008)

    DOI: 10.1253/circj.CJ-11-1014

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    その他リンク: http://search.jamas.or.jp/link/ui/2013248133

  • Deletion of the Angiotensin II Type 1a Receptor Prevents Atherosclerotic Plaque Rupture in Apolipoprotein E-/- Mice 査読

    Jun Aono, Jun Suzuki, Masaru Iwai, Masatsugu Horiuchi, Takayuki Nagai, Kazuhisa Nishimura, Katsuji Inoue, Akiyoshi Ogimoto, Hideki Okayama, Jitsuo Higaki

    ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY   32 ( 6 )   1453 - 1459   2012年6月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:LIPPINCOTT WILLIAMS & WILKINS  

    Objective-Angiotensin II is involved in the genesis of atherosclerosis. As the role of the angiotensin II type 1a (AT(1a)) receptor in plaque rupture is poorly understood, we assessed the hypothesis that the AT(1a) receptor contributes to atherosclerotic plaque rupture.
    Methods and Results-Atherosclerotic plaque rupture was induced by carotid artery ligation for 4 weeks followed by polyethylene cuff placement around the carotid in apolipoprotein E (ApoE)(-/-) and ApoE(-/-) AT(1a)(-/-) mice. The incidence of plaque rupture at 4 days after cuff placement was 72% in ApoE(-/-) mice compared with 24% in ApoE(-/-) AT(1a)(-/-) mice (P&lt;0.01). Lipid accumulation, macrophage infiltration, expression of inflammatory cytokines, nicotinamide adenine dinucleotide phosphate-oxidase activity, and matrix metalloproteinase-9 activity in atherosclerotic plaque were markedly attenuated in ApoE(-/-) AT(1a)(-/-) compared with ApoE(-/-) mice. Oxidized low-density lipoprotein inhibited macrophage migration in ApoE(-/-) macrophages. In contrast, oxidized low-density lipoprotein-induced macrophage trapping was abolished in ApoE(-/-) AT(1a)(-/-) macrophages, and this was associated with decreased CD36 expression and focal adhesion kinase activity.
    Conclusion-These results suggest that blocking the AT(1) receptor may reduce atherosclerotic plaque rupture and that AT(1a) receptor-mediated macrophage trapping, inflammation, oxidative stress, and matrix metalloproteinase activation may play crucial roles in plaque vulnerability. (Arterioscler Thromb Vasc Biol. 2012;32:1453-1459.)

    DOI: 10.1161/ATVBAHA.112.249516

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  • 難治性心不全を合併した心サルコイドーシスに対して心臓再同期療法、陽圧換気療法およびステロイド療法を施行した1例

    原 佳世, 西村 和久, 土居 寿之, 東 晴彦, 藤井 昭, 稲葉 慎二, 永井 啓行, 井上 勝次, 鈴木 純, 大木元 明義, 檜垣 實男

    心臓   44 ( 1 )   62 - 68   2012年1月

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    記述言語:日本語   出版者・発行元:(公財)日本心臓財団  

    症例は64歳、女性。2005年に完全房室ブロックのため、DDDペースメーカー植え込み術を施行された。2008年に左前脛骨部の皮膚生検からサルコイドーシスと確定診断された。2009年4月より労作時呼吸困難が出現し、徐々に増悪した。2010年1月には軽労作でも呼吸困難が出現するようになったため、精査目的で当院に紹介された。心エコー図検査で左室拡大、び漫性の壁運動低下(特に心室中隔基部と後壁の菲薄化)、Gaシンチグラフィや18F-FDG-PETで心臓への集積を認め心サルコイドーシスと診断した。心エコー図検査で右室心尖部ペーシングによる左室同期不全も認めたため、心臓再同期療法およびステロイド療法を開始した。また、終夜睡眠検査で中枢性優位の睡眠時無呼吸症候群の合併を認めたため、陽圧換気療法(adaptive servo-ventilation;ASV)も開始した。治療後、左室駆出率は22.5%から29.7%に、拡張末期左室容積も148mLから104mLに軽度改善したが、reverse remodelingは認めず心機能改善効果は軽度であった。心筋障害や左室remodelingの高度な症例での治療には一定の効果が認められたが限定的であった。このため、心不全早期からの治療介入が重要と考えられたため、文献的考察を加えて報告する。(著者抄録)

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    その他リンク: https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2012&ichushi_jid=J00679&link_issn=&doc_id=20120124160016&doc_link_id=%2Fah2sinzd%2F2012%2F004401%2F018%2F0062-0068%26dl%3D0&url=http%3A%2F%2Fwww.medicalonline.jp%2Fjamas.php%3FGoodsID%3D%2Fah2sinzd%2F2012%2F004401%2F018%2F0062-0068%26dl%3D0&type=MedicalOnline&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00004_2.gif

  • A cluster of black holes and multiple plaque ruptures on optical coherence tomography 13 years after bare-metal stent implantation. 国際誌

    Shinji Inaba, Hideki Okayama, Tatsunori Takahashi, Haruhiko Higashi, Kazuhisa Nishimura, Katsuji Inoue, Akiyoshi Ogimoto, Jitsuo Higaki

    International journal of cardiology   152 ( 3 )   e47-8   2011年11月

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  • The differences in left ventricular torsional behavior between patients with hypertrophic cardiomyopathy and hypertensive heart disease. 国際誌

    Makoto Saito, Hideki Okayama, Toyofumi Yoshii, Go Hiasa, Takumi Sumimoto, Shinji Inaba, Kazuhisa Nishimura, Katsuji Inoue, Akiyoshi Ogimoto, Tomoaki Ohtsuka, Jun-Ichi Funada, Yuji Shigematsu, Jitsuo Higaki

    International journal of cardiology   150 ( 3 )   301 - 6   2011年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    BACKGROUND: The aim of this study was to investigate the differences in left ventricular (LV) twisting behavior between patients with hypertrophic cardiomyopathy (HCM) and hypertensive heart disease (HHD). METHODS: Forty-four patients with HCM (mean age, 63±15 years), 35 patients with HHD (mean age, 63±13 years) and 20 age and sex-matched control subjects were evaluated. After a standard echocardiographic examination, LV twist and twisting velocity profiles from apical and basal short-axis images were analyzed using two-dimensional speckle tracking imaging. RESULTS: LV diastolic and systolic dimensions, and ejection fraction were not significantly different among the groups. LV mass index and early diastolic mitral annular velocity were not significantly different between the HCM and HHD groups. The peak torsion in the HCM and HHD groups was significantly greater than that in the control group. The peak untwisting velocity in the HCM group was comparable with that in the control group. However, when the peak untwisting velocity was corrected by peak torsion, this ratio was significantly decreased in the HCM group compared with the values in the HHD and control groups. The time to peak untwisting velocity in the HCM group was significantly longer than the values in the HHD and control groups. CONCLUSIONS: These results suggest that enhanced peak torsion in HCM may improve untwisting behavior, but this mechanism fails to fully compensate for impaired untwisting behavior compared with HHD.

    DOI: 10.1016/j.ijcard.2010.04.040

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  • Usefulness of transthoracic Doppler echocardiography for noninvasive assessment of coronary blood flow in a patient with symptomatic myocardial bridging. 国際誌

    Shinji Inaba, Hideki Okayama, Haruhiko Higashi, Kazuhisa Nishimura, Katsuji Inoue, Akiyoshi Ogimoto, Jitsuo Higaki

    European journal of echocardiography : the journal of the Working Group on Echocardiography of the European Society of Cardiology   12 ( 3 )   E15   2011年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Myocardial bridging (MB) is a congenital anomaly characterized by systolic compression of the tunnelled arterial segment. MB may cause myocardial ischaemia due to abnormal coronary blood flow. We report a case of MB in which transthoracic Doppler echocardiography was used to evaluate the long-term effect of beta-blocker therapy on abnormal coronary blood flow. In this case, beta-blocker therapy with bisoprolol (5.0 mg/day) for 1 month eliminated the patient's symptoms and normalized coronary blood flow through the tunnelled arterial segment.

    DOI: 10.1093/ejechocard/jeq159

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  • 3D経食道心エコー図検査が外科的治療方針の決定に有用であった感染性心内膜炎の1例

    木下 将城, 西村 和久, 稲葉 慎二, 藤井 昭, 永井 啓行, 井上 勝次, 鈴木 純, 大木元 明義, 檜垣 實男, 岡山 英樹

    超音波医学   38 ( 1 )   41 - 41   2011年1月

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    記述言語:日本語   出版者・発行元:(公社)日本超音波医学会  

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  • Relationship between smaller calcifications and lipid-rich plaques on integrated backscatter-intravascular ultrasound. 国際誌

    Shinji Inaba, Hideki Okayama, Jun-Ichi Funada, Hidetoshi Hashida, Go Hiasa, Takumi Sumimoto, Yasunori Takata, Kazuhisa Nishimura, Katsuji Inoue, Akiyoshi Ogimoto, Tomoaki Ohtsuka, Jitsuo Higaki

    International journal of cardiology   145 ( 2 )   347 - 348   2010年11月

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    記述言語:英語  

    We evaluated the relationship between coronary calcification and plaque characteristics using integrated backscatter-intravascular ultrasound (IB-IVUS), focusing on spotty calcification. Seventy-two patients with culprit plaques containing spotty calcification were evaluated. The average degree of all the spotty calcifications (averaged arc) negatively correlated with the % lipid volume (LV) on IB-IVUS. Multivariate analysis showed the averaged arc was an independent predictor of % LV. Our observations suggest that smaller plaque calcifications are associated with lipid-rich characteristics in patients with a spotty calcification pattern.

    DOI: 10.1016/j.ijcard.2009.12.011

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  • 冠動脈プラークの進展に伴いsignet-ring like appearanceを呈した1症例 冠動脈CTを用いた6年にわたる長期観察

    原 佳世, 稲葉 慎二, 西村 和久, 井上 勝次, 鈴木 純, 大木元 明義, 岡山 英樹, 檜垣 實男, 城戸 輝人, 東野 博, 望月 輝一

    日本心臓病学会誌   5 ( Suppl.I )   388 - 388   2010年8月

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    記述言語:日本語   出版者・発行元:(一社)日本心臓病学会  

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  • 右房-下大静脈合流部を起源とする巨大粘液腫の1例

    原 佳世, 西村 和久, 土居 寿之, 東 晴彦, 藤井 昭, 稲葉 慎二, 井上 勝次, 鈴木 純, 大木元 明義, 岡山 英樹, 檜垣 實男

    日本心臓病学会誌   5 ( Suppl.I )   485 - 485   2010年8月

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    記述言語:日本語   出版者・発行元:(一社)日本心臓病学会  

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  • Dysfunctional central hemodynamic regulation after daily meal intake in metabolic syndrome

    Jun-ichi Funada, Yasunori Takata, Hidetoshi Hashida, Yuji Matsumoto, Sumiko Sato, Go Hiasa, Katsuji Inoue, Jitsuo Higaki, Hideki Okayama

    Atherosclerosis   210 ( 1 )   268 - 273   2010年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Objective: Postprandial hyperlipidemia and insulin resistance play roles in the development of atherosclerosis in metabolic syndrome (MetS)
    however, the clinical significance of postprandial hemodynamic variables in this condition is still in question. The aim of this study was to investigate hemodynamic and metabolic indicators related to MetS after a mixed meal (Calorie mate, 500. kcal). Methods: Of 107 participants undergoing this investigation, 24 fulfilled ATPIII criteria for MetS. The remaining 83 subjects were controls. Both the augmentation index (AI) and late systolic blood pressure in the radial artery (rSBP2) as an index of central blood pressure were monitored using HEM-9000AI (Omron Healthcare, Kyoto, Japan) until 240. min after meal intake. Results: Both AI and rSBP2 showed significant decreases after meal intake in both groups. Changes in postprandial AI showed a similar trend in the groups. rSBP2 reduction 60. min after meal ingestion was also comparable, -7.5 ± 2.3. mmHg in MetS
    -7.8 ± 0.9. mmHg in control
    however, delta rSBP2-120, the degree of rSBP2 reduction 120. min after meal ingestion comparing the fasting level, showed a significant difference between 2 groups, -0.5 ± 2.0. mmHg in MetS
    -5.3 ± 0.9. mmHg in control, P&lt
    0.02. Stepwise regression analysis revealed low-density-lipoprotein cholesterol (β=0.333, P=0.001), high-density-lipoprotein cholesterol (β=-0.209, P&lt
    0.05) and systolic blood pressure (β=-0.377, P&lt
    0.001) as independent variables for determining delta rSBP2-120. Conclusion: Subjects with MetS exhibit signs of blunted rSBP2 (=central blood pressure) regulation after food intake. Dysfunctional postprandial hemodynamic regulation is another feature of MetS that may contribute to the progression of cardiovascular disease. © 2009 Elsevier Ireland Ltd.

    DOI: 10.1016/j.atherosclerosis.2009.11.003

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  • 心アミロイドーシスの1剖検例における病理組織所見と局所心機能の関連の検討

    清家 史靖, 井上 勝次, 西村 和久, 佐々木 香織, 青野 潤, 稲葉 慎二, 永井 啓行, 鈴木 純, 大木元 明義, 大塚 知明, 岡山 英樹, 檜垣 實男

    Circulation Journal   73 ( Suppl.II )   994 - 994   2009年4月

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  • スペックルトラッキング法を用いて左室の捻れおよび回旋運動の定量評価を行った多量心嚢液貯留例

    佐々木 香織, 井上 勝次, 西村 和久, 清家 史靖, 青野 潤, 稲葉 慎二, 永井 啓行, 鈴木 純, 大木元 明義, 大塚 知明, 岡山 英樹, 檜垣 實男

    Circulation Journal   73 ( Suppl.II )   995 - 995   2009年4月

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  • 冠動脈プラークの石灰化パターンと組織性状との関連 IB-IVUSによる検討

    稲葉 慎二, 岡山 英樹, 船田 淳一, 橋田 英俊, 西村 和久, 井上 勝次, 大木元 明義, 大塚 知明, 高田 康徳, 日浅 豪, 住本 巧, 檜垣 實男

    日本心臓病学会誌   2 ( Suppl.I )   291 - 291   2008年8月

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    記述言語:日本語   出版者・発行元:(一社)日本心臓病学会  

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  • 陳旧性心筋梗塞患者の壁運動評価におけるAutomated function imaging(AFI)の有用性に関する検討

    西村 和久, 岡山 英樹, 井添 洋輔, 齋藤 実, 上谷 晃由, 稲葉 慎二, 永井 啓行, 倉田 聖, 大木元 明義, 大塚 知明, 吉井 豊史, 井上 勝次, 日浅 豪, 住元 巧, 檜垣 實男

    Circulation Journal   71 ( Suppl.III )   973 - 973   2007年10月

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  • 急性心不全患者における冠血流予備能に対するカルペリチドの効果の検討

    齋藤 実, 岡山 英樹, 上谷 晃由, 稲葉 慎二, 永井 啓行, 西村 和久, 倉田 聖, 大木元 明義, 大塚 知明, 吉井 豊史, 井上 勝次, 日浅 豪, 住元 巧, 檜垣 實男

    Circulation Journal   71 ( Suppl.III )   969 - 969   2007年10月

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  • 肥大型心筋症における左室dyssynchronyの検討

    西村 和久, 岡山 英樹, 齋藤 実, 上谷 晃由, 稲葉 慎二, 永井 啓行, 倉田 聖, 大木元 明義, 大塚 知明, 吉井 豊史, 井上 勝次, 日浅 豪, 住元 巧, 檜垣 實男

    Circulation Journal   71 ( Suppl.III )   967 - 967   2007年10月

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    記述言語:日本語   出版者・発行元:(一社)日本循環器学会  

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  • 閉塞性肥大型心筋症の局所心機能におけるシベンゾリンの効果の検討

    齋藤 実, 岡山 英樹, 上谷 晃由, 稲葉 慎二, 永井 啓行, 西村 和久, 倉田 聖, 大木元 明義, 大塚 知明, 吉井 豊史, 井上 勝次, 日浅 豪, 住元 巧, 檜垣 實男

    Circulation Journal   71 ( Suppl.III )   967 - 967   2007年10月

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    記述言語:日本語   出版者・発行元:(一社)日本循環器学会  

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  • 後負荷の低下によるstrain及びtorsionの変化について 2D speckle tracking法による検討

    齋藤 実, 重見 晋, 佐々木 康浩, 藤田 鉄平, 井添 洋輔, 上谷 晃由, 稲葉 慎二, 永井 啓行, 西村 和久, 倉田 聖, 大木元 明義, 大塚 知明, 岡山 英樹, 檜垣 實男, 吉井 豊史, 井上 勝次, 日浅 豪, 山田 忠克, 住元 巧

    Circulation Journal   71 ( Suppl.II )   885 - 885   2007年4月

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    記述言語:日本語   出版者・発行元:(一社)日本循環器学会  

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  • エコーガイド下経皮的末梢動脈インターベンションが有用であった浅大腿動脈慢性完全閉塞の一例

    西村 和久, 日浅 豪, 吉井 豊史, 井上 勝次, 山田 忠克, 住元 巧, 岡山 英樹, 重見 晋, 佐々木 康浩, 藤田 鉄平, 井添 洋輔, 上谷 晃由, 齋藤 実, 稲葉 慎二, 永井 啓行, 倉田 聖, 大木元 明義, 大塚 知明, 檜垣 實男

    Circulation Journal   71 ( Suppl.II )   882 - 882   2007年4月

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    記述言語:日本語   出版者・発行元:(一社)日本循環器学会  

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  • Serum markers of angiogenesis and myocardial ultrasonic tissue characterization in patients with dilated cardiomyopathy

    Tomoaki Ohtsuka, Katsuji Inoue, Yuji Hara, Norikatsu Morioka, Kiyotaka Ohshima, Jun Suzuki, Akiyoshi Ogimoto, Yuji Shigematsu, Jitsuo Higaki

    European Journal of Heart Failure   7 ( 4 )   689 - 695   2005年6月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Background and aims: It has been proven that a disturbance in angiogenesis contributes to the progression of myocardial interstitial fibrosis in idiopathic dilated cardiomyopathy (DCM). This study was designed to evaluate the relationship between serum activity of angiogenic factors and myocardial ultrasonic tissue characterization in patients with DCM. Methods and results: We studied 30 patients with DCM and 15 healthy control subjects. Serum levels of vascular endothelial growth factor (VEGF), interleukin (IL)-4 and IL-13 were measured using enzyme-linked immunosorbent assay. We determined calibrated myocardial integrated backscatter (IB) as the value of myocardial interstitial fibrosis using ultrasonic tissue characterization and also quantified the magnitude of cyclic variations in IB (CV-IB). Serum levels of VEGF and IL-13 were significantly higher in patients with DCM than in control subjects (both P&lt
    0.05). Calibrated IB was significantly higher and CV-IB was markedly lower in patients with DCM than in control subjects (both P&lt
    0.01). In patients with DCM, the levels of IL-13 significantly correlated with calibrated IB (r=0.520, P=0.018). In addition, there was a significant negative correlation between levels of VEGF and CV-IB (r=-0.611, P=0.007). Conclusion: The increase in serum VEGF and IL-13 may be closely related to alterations in myocardial texture in DCM. © 2004 European Society of Cardiology. Published by Elsevier B.V. All rights reserved.

    DOI: 10.1016/j.ejheart.2004.09.011

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  • Pure Right Ventricular Infarction

    INOUE Katsuji, MATSUOKA Hiroshi, KAWAKAMI Hideo, KOYAMA Yasushi, NISHIMURA Kazuhisa, ITO Taketoshi

    Circulation journal : official journal of the Japanese Circulation Society   66 ( 2 )   213 - 215   2002年1月

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    記述言語:英語   出版者・発行元:社団法人日本循環器学会  

    A 76-year-old man with chest pain was admitted to hospital where electrocardiography (ECG) showed ST-segment elevation in leads V<sub>1-4</sub>, indicative of acute anterior myocardial infarction. ST-segment elevation was also present in the right precordial leads V<sub>4R-6R</sub>. Emergency coronary angiography revealed that the left coronary artery was dominant and did not have significant stenosis. Aortography showed ostial occlusion of the right coronary artery (RCA). Left ventriculography showed normal function and right ventriculography showed a dilated right ventricle and severe hypokinesis of the right ventricular free wall. Conservative treatment was selected because the patient's symptoms soon ameliorated and his hemodynamics was stable. <sup>99m</sup>Tc-pyrophosphate and <sup>201</sup>Tl dual single-photon emission computed tomography showed uptake of <sup>99m</sup>Tc-pyrophosphate in only the right ventricular free wall, but no uptake of <sup>99m</sup>Tc-pyrophosphate and no perfusion defect of <sup>201</sup>Tl in the left ventricle. The peak creatine kinase (CK) and CK-MB were 1,381 IU/L and 127 IU/L, respectively. His natural course was favorable and the chest pain disappeared under medication. Two months after the onset, the ECG showed poor R progression in leads V<sub>1-4</sub> indicating an old anterior infarction. Coronary angiography confirmed the ostial stenosis of the hypoplastic RCA. This was a case of pure right ventricular free wall infarction because of the occlusion of the ostium of the hypoplastic RCA, but not of the right ventricular branch. Because the electrocardiographic findings resemble those of an acute anterior infarction, it is important to consider pure right ventricular infarction in the differential diagnosis. (<i>Circ J</i> 2002; <b>66:</b> 213 - 215)<br>

    DOI: 10.1253/circj.66.213

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  • A case of unstable angina whose ischemic area was clearly detected by contrast echocardiography using harmonic power Doppler imaging

    Hideo Kawakami, Hiroshi Matsuoka, Yasushi Koyama, Katsuji Inoue, Kazuhisa Nishimura, Taketoshi Ito

    Respiration and Circulation   49 ( 3 )   299 - 303   2001年3月

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    記述言語:中国語   掲載種別:研究論文(学術雑誌)  

    A 67-year-old man was admitted to our hospital due to unstable angina. Electrocardiography at rest revealed ST segment depression in II, aVF, and V 4 to V 6 and further depression was observed during chest pain. 99mTc -tetrofosmin SPECT demonstrated perfusion defect at the inferior area. We performed harmonic power Doppler imaging with contrast echocardiography using a digital ultrasound system (SYSTEM FIVE, Vingmed, Norway). Initially, harmonic power Doppler imaging was obtained by intermittent (one per 6 cardiac cycles) imaging. Perfusion defect was detected neither at the apical four chamber view nor at the two chamber view. To decrease the supply of microbubbles, we changed the intermittent rate from one per six to one per three cardiac cycles. It was then that the perfusion defect in the lateral area was clearly detected at the apical four chamber view. Coronary arteriography revealed 90 % stenosis at the mid left circumflex artery. After percutaneous transluminal coronary angioplasty at the mid circumflex artery, the perfusion defect in the lateral area was disappeared and normalized. Harmonic power Doppler imaging by contrast echocardiography was useful for detecting the ischemic area in a patient with unstable angina.

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  • Isolated Left Coronary Ostial Stenosis as a Result of Fibromuscular Dysplasia in a Young Man

    KAWAKAMI Hideo, MATSUOKA Hiroshi, KOYAMA Yasushi, SAEKI Hideyuki, INOUE Katsuji, NISHIMURA Kazuhisa, ITOU Kaketoshi, SATOU Hiromitsu, TOMINO Tetsuo

    Japanese circulation journal   64 ( 12 )   988 - 989   2000年12月

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    記述言語:英語   出版者・発行元:社団法人日本循環器学会  

    A 28-year-old man was admitted to hospital for investigation of a 2-week history of angina occurring on exertion. Coronary angiography showed an isolated left coronary ostial stenosis and left main trunk plasty was performed 2 weeks later. The pathological diagnosis of the left coronary ostial stenosis was fibromuscular dysplasia, which makes this a rare case.

    DOI: 10.1253/jcj.64.988

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    その他リンク: http://search.jamas.or.jp/link/ui/2001098851

  • 小腸迷入膵が原因と考えられた老年者消化管出血の1例

    井上 勝次, 北見 裕, 佐伯 秀幸, 伊賀瀬 道也, 福岡 富和, 間口 元文, 大蔵 隆文, 小原 克彦, 児玉 光司, 日和田 邦男

    日本老年医学会雑誌   35 ( 1 )   53 - 56   1998年1月

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    記述言語:日本語   出版者・発行元:The Japan Geriatrics Society  

    老年者の消化管出血は日常診療でしばしば遭遇する. しかし, 老年者では無症状のことが少なくなく, 見逃される可能性があり注意が必要である. 我々は71歳女性で消化管出血による高度の貧血をきたした症例を経験した. 患者の出血源は上部消化管造影, 小腸造影, 注腸造影および内視鏡検査では発見できず, 腹部血管造影で初めて出血源と思われる小腸腫瘍を同定し得た. 小腸切除術の結果, 腫瘍は径4×3×3.5cm大の管外性に発育した迷入膵と診断した. 消化管出血の原因として小腸からの出血が疑われる場合, 小腸造影では診断因難な壁外発育性の腫瘍や血管性病変を考慮し, 一度は腹部血管造影を試みるべきであると思われた. 小腸腫瘍からの出血は消化管出血のなかでも比較的まれであり, 特に本症例のように出血源と考えられ外科的切除にいたった小腸腫瘍が病理組織学的に迷入膵と診断されることは非常にまれである.

    DOI: 10.3143/geriatrics.35.53

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    その他リンク: http://search.jamas.or.jp/link/ui/1998161890

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