Organization
Graduate School of Medicine Program for Medical Sciences Associate Professor
Title
Associate Professor
Contact information
External link
Mizoue Shiro
Degree
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医学博士 ( 愛媛大学 )
Research Areas
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Life Science / Ophthalmology
Education
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Ehime University
- 2005
Country： Japan
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Ehime University School of Medicine
- 1995
Country： Japan
Professional Memberships
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日本眼科手術学会
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日本緑内障学会
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日本眼科学会
Qualification acquired
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医師免許
Research Projects
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The role of Angiotensin II receptor subtypes in retinal ganglion cell
2007 - 2009
Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B)
MIZOUE Shiro
Grant amount：\2750000 （ Direct Cost: \2300000 、 Indirect Cost：\450000 ）
The AT1a angiotensin II receptor has been shown to be expressed in the retinal ganglion cells of wild type mice (C57BL/6J). Using intravitreal injection of NMDA, we were able to create a highly reproducible model of apoptosis in retinal ganglion cells. To examine the association between apoptosis and the angiotensin II system, we compared NMDA-induced retinal ganglion cell damage in AT1a (AT1aKO) and AT2 (AT2KO) receptor knock-out mice with that in wild type mice (C57BL/6J). No significant difference in ganglion cell count or inner plexiform layer (IPL) thickness was observed between the AT1aKO, AT2KO and wild type mice.