Single-cell DNA and RNA sequencing reveals the dynamics of intra-tumor heterogeneity in a colorectal cancer model

3.Ono, H., Arai, Y., Furukawa, E., Narushima, D., Matsuura, T., Nakamura, H., Shiokawa, D., Nagai, M., Imai, T., Mimori, K., Okamoto, K., Hippo, Y., Shibata, T., and Kato, M.

BMC Biol.   2021.9

Integrative analyses of gene expression and chemosensitivity of patient-derived ovarian cancer spheroids link G6PD-driven redox metabolism to cisplatin chemoresistance

4.Yamawaki, K., Mori, Y., Sakai, H., Kanda, Y., Shiokawa, D., Ueda, H., Ishiguro, T., Yoshihara, K., Nagasaka, K., Onda, T., Kato, T., Kondo, T., Enomoto, T., and Okamoto, K.

Cancer Lett.   2021.8

Slow-Cycling Cancer Stem Cells Regulate Progression and Chemoresistance in Colon Cancer

Shiokawa D, Sakai H, Ohata H, Miyazaki T, Kanda Y, Sekine S, Narushima D, Hosokawa M, Kato M, Suzuki Y, Takeyama H, Kambara H, Nakagama H, Okamoto K.

Cancer Res.   2020.10

NOX1-Dependent mTORC1 Activation via S100A9 Oxidation in Cancer Stem-like Cells Leads to Colon Cancer Progression

Ohata H, Shiokawa D, Obata Y, Sato A, Sakai H, Fukami M, Hara W, Taniguchi H, Ono M, Nakagama H, Okamoto K.

Cell Rep.   2019.7

Heterogeneity among Lgr5-positive colon stem cells.

Shiokawa D, Okamoto K.

Mol Cell Oncol.   2017.6

The Induction of Selected Wnt Target Genes by Tcf1 Mediates Generation of Tumorigenic Colon Stem Cells

Shiokawa D, Sato A, Ohata H, Mutoh M, Sekine S, Kato M, Shibata T, Nakagama H, Okamoto K.

Cell Rep.   2017.5

DNase γ is the effector endonuclease for internucleosomal DNA fragmentation in necrosis

Mizuta R, Araki S, Furukawa M, Furukawa Y, Ebara S, Shiokawa D, Hayashi K, Tanuma S, Kitamura D.

PLoS One   2013.12

DNase gamma-dependent and -independent apoptotic DNA fragmentations in Ramos Burkitt's lymphoma cell line

Mizuta R, Mizuta M, Araki S, Suzuki K, Ebara S, Furukawa Y, Shiokawa D, Tanuma S, Kitamura D.

Biomed Res.   2009.6

Cytoplasmic tethering is involved in synergistic inhibition of p53 by Mdmx and Mdm2.

Ohtsubo C, Shiokawa D, Kodama M, Gaiddon C, Nakagama H, Jochemsen AG, Taya Y, Okamoto K.

Cancer Sci.   2009.6

DNase X is a glycosylphosphatidylinositol-anchored membrane enzyme that provides a barrier to endocytosis-mediated transfer of a foreign gene

Shiokawa D, Matsushita T, Shika Y, Shimizu M, Maeda M, Tanuma S.

J Biol Chem.   2007.6

Stage-specific expression of DNasegamma during B-cell development and its role in B-cell receptor-mediated apoptosis in WEHI-231 cells

Shiokawa D, Shika Y, Araki S, Sunaga S, Mizuta R, Kitamura D, Tanuma S.

Cell Death Differ.   2007.5

Structure basis for the inhibitory mechanism of a novel DNase gamma-specific inhibitor, DR396

Sunaga S, Yoshimori A, Shiokawa D, Tanuma S.

Bioorg Med Chem.   2006.6

Action of apoptotic endonuclease DNase gamma on naked DNA and chromatin substrates

Mizuta R, Mizuta M, Araki S, Shiokawa D, Tanuma S, Kitamura D.

Biochem Biophys Res Commun.   2006.5

cDNA cloning and functional characterization of Xenopus laevis DNase gamma

Shiokawa D, Hatanaka T, Hatanaka M, Shika Y, Nishikawa A, Tanuma S.

Apoptosis   2006.4

Physical and biochemical properties of mammalian DNase X proteins: non-AUG translation initiation of porcine and bovine mRNAs for DNase X

Shiokawa D, Shika Y, Saito K, Yamazaki K, Tanuma S.

Biochem J.   2005.12

Involvement of DNase gamma in the resected double-strand DNA breaks in immunoglobulin genes

Okamoto M, Okamoto N, Yashiro H, Shiokawa D, Sunaga S, Yoshimori A, Tanuma S, Kitamura D.

Biochem Biophys Res Commun.   2005.2

A novel inhibitor that protects apoptotic DNA fragmentation catalyzed by DNase gamma

Sunaga S, Kobayashi T, Yoshimori A, Shiokawa D, Tanuma S.

Biochem Biophys Res Commun.   2004.12

Differential DNases are selectively used in neuronal apoptosis depending on the differentiation state

Shiokawa D, Tanuma S.

Cell Death Differ.   2004.10

Characterization of the human DNAS1L2 gene and the molecular mechanism for its transcriptional activation induced by inflammatory cytokines

Shiokawa D, Matsushita T, Kobayashi T, Matsumoto Y, Tanuma S.

Genomics   2004.7

Expression of DNase gamma during Fas-independent apoptotic DNA fragmentation in rodent hepatocytes

Higami Y, Tsuchiya T, To K, Chiba T, Yamaza H, Shiokawa D, Tanuma S, Shimokawa I.

Cell Tissue Res.   2004.6

Aging increases DNase gamma, an apoptosis-related endonuclease, in rat liver nuclei: effect of dietary restriction

Tanaka K, Higami Y, Tsuchiya T, Shiokawa D, Tanuma S, Ayabe H, Shimokawa I.

Exp Gerontol.   2004.2

Identification of two functional nuclear localization signals in DNase gamma and their roles in its apoptotic DNase activity

Shiokawa D, Shika Y, Tanuma S.

Biochem J.   2003.12

Involvement of DNase gamma in apoptotic DNA fragmentation in histiocytic necrotizing lymphadenitis

Higami Y, To K, Ohtani H, Masui K, Iwasaki K, Shiokawa D, Tanuma S, Shimokawa I.

Virchows Arch.   2003.8

Involvement of DNase gamma in apoptosis associated with myogenic differentiation of C2C12 cells

Shiokawa D, Kobayashi T, Tanuma S.

J Biol Chem.   2002.8

Isolation and characterization of the DLAD/Dlad genes, which lie head-to-head with the genes for urate oxidase

Shiokawa D, Tanuma SI.

Biochem Biophys Res Commun.   2001.11

DNA fragmentation in ischemic core and penumbra in focal cerebral ischemia in rats

Yao H, Takasawa R, Fukuda K, Shiokawa D, Sadanaga-Akiyoshi F, Ibayashi S, Tanuma S, Uchimura H.

Brain Res Mol Brain Res.   2001.7

Characterization of human DNase I family endonucleases and activation of DNase gamma during apoptosis

Shiokawa D, Tanuma S.

Biochemistry   2001.1

Characterization of two DNase gamma-specific monoclonal antibodies and the in situ detection of DNase gamma in the nuclei of apoptotic rat thymocytes

Shiokawa D, Tanaka M, Kimura T, Hashizume K, Takasawa R, Ohyama H, Fujita K, Yamada T, Tanuma S.

Biochem Biophys Res Commun.   2000.8

Cloning of a cDNA encoding a rat DNase II-like acid DNase

Tanuma S, Shiokawa D.

Biochem Biophys Res Commun.   1999.11

DLAD, a novel mammalian divalent cation-independent endonuclease with homology to DNase II

Shiokawa D, Tanuma S.

Nucleic Acids Res.   1999.10

Cloning of cDNAs encoding porcine and human DNase II

Shiokawa D, Tanuma S.

Biochem Biophys Res Commun.   1998.6

Molecular cloning and expression of a cDNA encoding an apoptotic endonuclease DNase gamma

Shiokawa D, Tanuma S.

Biochem J.   1998.6

cDNA cloning of human DNase gamma: chromosomal localization of its gene and enzymatic properties of recombinant protein

Shiokawa D, Hirai M, Tanuma S.

Apoptosis   1998.3

Purification, characterization, and amino acid sequencing of DNase gamma from rat spleen

Shiokawa D, Iwamatsu A, Tanuma S.

Arch Biochem Biophys.   1997.10

Purification and properties of DNase gamma from apoptotic rat thymocytes

Shiokawa D, Ohyama H, Yamada T, Tanuma S.

Biochem J.   1997.9

Inhibitors of poly(ADP-ribose) polymerase suppress nuclear fragmentation and apoptotic-body formation during apoptosis in HL-60 cells

Shiokawa D, Maruta H, Tanuma S.

FEBS Lett.   1997.8

Occurrence of DNase gamma-like apoptotic endonucleases in hematopoietic cells in Xenopus laevis and their relation to metamorphosis

Nishikawa A, Shiokawa D, Umemori K, Hayashi H, Tanuma S.

Biochem Biophys Res Commun.   1997.2

An endonuclease responsible for apoptosis

Tanuma S, Shiokawa D.

Prog Mol Subcell Biol.   1996

Identification of an endonuclease responsible for apoptosis in rat thymocytes

Shiokawa D, Ohyama H, Yamada T, Takahashi K, Tanuma S.

Eur J Biochem.   1994.11

Multiple forms of nuclear deoxyribonuclease in rat thymocytes

Tanuma S, Shiokawa D.

Biochem Biophys Res Commun.   1994.9

Sodium benzylideneascorbate induces apoptosis in HIV-replicating U1 cells

Aoki K, Nakashima H, Hattori T, Shiokawa D, Ni-imi E, Tanimoto Y, Maruta H, Uchiumi F, Kochi M, Yamamoto N, et al.

FEBS Lett.   1994.8

Induction of DNA fragmentation in human myelogenous leukemic cell lines by sodium 5,6-benzylidene-L-ascorbate and its related compounds

Kuribayashi N, Sakagami H, Sakagami T, Niimi E, Shiokawa D, Ikekita M, Takeda M, Tanuma S.

Anticancer Res.   1994.5

Benzylideneascorbate induces apoptosis in L929 tumor cells

Tanuma S, Shiokawa D, Tanimoto Y, Ikekita M, Sakagami H, Takeda M, Fukuda S, Kochi M.

Biochem Biophys Res Commun.   1993.6