Single-cell DNA and RNA sequencing reveals the dynamics of intra-tumor heterogeneity in a colorectal cancer model

3.Ono, H., Arai, Y., Furukawa, E., Narushima, D., Matsuura, T., Nakamura, H., Shiokawa, D., Nagai, M., Imai, T., Mimori, K., Okamoto, K., Hippo, Y., Shibata, T., and Kato, M.

BMC Biol.   2021年9月

Integrative analyses of gene expression and chemosensitivity of patient-derived ovarian cancer spheroids link G6PD-driven redox metabolism to cisplatin chemoresistance

4.Yamawaki, K., Mori, Y., Sakai, H., Kanda, Y., Shiokawa, D., Ueda, H., Ishiguro, T., Yoshihara, K., Nagasaka, K., Onda, T., Kato, T., Kondo, T., Enomoto, T., and Okamoto, K.

Cancer Lett.   2021年8月

Slow-Cycling Cancer Stem Cells Regulate Progression and Chemoresistance in Colon Cancer

Shiokawa D, Sakai H, Ohata H, Miyazaki T, Kanda Y, Sekine S, Narushima D, Hosokawa M, Kato M, Suzuki Y, Takeyama H, Kambara H, Nakagama H, Okamoto K.

Cancer Res.   2020年10月

NOX1-Dependent mTORC1 Activation via S100A9 Oxidation in Cancer Stem-like Cells Leads to Colon Cancer Progression

Ohata H, Shiokawa D, Obata Y, Sato A, Sakai H, Fukami M, Hara W, Taniguchi H, Ono M, Nakagama H, Okamoto K.

Cell Rep.   2019年7月

Heterogeneity among Lgr5-positive colon stem cells.

Shiokawa D, Okamoto K.

Mol Cell Oncol.   2017年6月

The Induction of Selected Wnt Target Genes by Tcf1 Mediates Generation of Tumorigenic Colon Stem Cells

Shiokawa D, Sato A, Ohata H, Mutoh M, Sekine S, Kato M, Shibata T, Nakagama H, Okamoto K.

Cell Rep.   2017年5月

DNase γ is the effector endonuclease for internucleosomal DNA fragmentation in necrosis

Mizuta R, Araki S, Furukawa M, Furukawa Y, Ebara S, Shiokawa D, Hayashi K, Tanuma S, Kitamura D.

PLoS One   2013年12月

DNase gamma-dependent and -independent apoptotic DNA fragmentations in Ramos Burkitt's lymphoma cell line

Mizuta R, Mizuta M, Araki S, Suzuki K, Ebara S, Furukawa Y, Shiokawa D, Tanuma S, Kitamura D.

Biomed Res.   2009年6月

Cytoplasmic tethering is involved in synergistic inhibition of p53 by Mdmx and Mdm2.

Ohtsubo C, Shiokawa D, Kodama M, Gaiddon C, Nakagama H, Jochemsen AG, Taya Y, Okamoto K.

Cancer Sci.   2009年6月

DNase X is a glycosylphosphatidylinositol-anchored membrane enzyme that provides a barrier to endocytosis-mediated transfer of a foreign gene

Shiokawa D, Matsushita T, Shika Y, Shimizu M, Maeda M, Tanuma S.

J Biol Chem.   2007年6月

Stage-specific expression of DNasegamma during B-cell development and its role in B-cell receptor-mediated apoptosis in WEHI-231 cells

Shiokawa D, Shika Y, Araki S, Sunaga S, Mizuta R, Kitamura D, Tanuma S.

Cell Death Differ.   2007年5月

Structure basis for the inhibitory mechanism of a novel DNase gamma-specific inhibitor, DR396

Sunaga S, Yoshimori A, Shiokawa D, Tanuma S.

Bioorg Med Chem.   2006年6月

Action of apoptotic endonuclease DNase gamma on naked DNA and chromatin substrates

Mizuta R, Mizuta M, Araki S, Shiokawa D, Tanuma S, Kitamura D.

Biochem Biophys Res Commun.   2006年5月

cDNA cloning and functional characterization of Xenopus laevis DNase gamma

Shiokawa D, Hatanaka T, Hatanaka M, Shika Y, Nishikawa A, Tanuma S.

Apoptosis   2006年4月

Physical and biochemical properties of mammalian DNase X proteins: non-AUG translation initiation of porcine and bovine mRNAs for DNase X

Shiokawa D, Shika Y, Saito K, Yamazaki K, Tanuma S.

Biochem J.   2005年12月

Involvement of DNase gamma in the resected double-strand DNA breaks in immunoglobulin genes

Okamoto M, Okamoto N, Yashiro H, Shiokawa D, Sunaga S, Yoshimori A, Tanuma S, Kitamura D.

Biochem Biophys Res Commun.   2005年2月

A novel inhibitor that protects apoptotic DNA fragmentation catalyzed by DNase gamma

Sunaga S, Kobayashi T, Yoshimori A, Shiokawa D, Tanuma S.

Biochem Biophys Res Commun.   2004年12月

Differential DNases are selectively used in neuronal apoptosis depending on the differentiation state

Shiokawa D, Tanuma S.

Cell Death Differ.   2004年10月

Characterization of the human DNAS1L2 gene and the molecular mechanism for its transcriptional activation induced by inflammatory cytokines

Shiokawa D, Matsushita T, Kobayashi T, Matsumoto Y, Tanuma S.

Genomics   2004年7月

Expression of DNase gamma during Fas-independent apoptotic DNA fragmentation in rodent hepatocytes

Higami Y, Tsuchiya T, To K, Chiba T, Yamaza H, Shiokawa D, Tanuma S, Shimokawa I.

Cell Tissue Res.   2004年6月

Aging increases DNase gamma, an apoptosis-related endonuclease, in rat liver nuclei: effect of dietary restriction

Tanaka K, Higami Y, Tsuchiya T, Shiokawa D, Tanuma S, Ayabe H, Shimokawa I.

Exp Gerontol.   2004年2月

Identification of two functional nuclear localization signals in DNase gamma and their roles in its apoptotic DNase activity

Shiokawa D, Shika Y, Tanuma S.

Biochem J.   2003年12月

Involvement of DNase gamma in apoptotic DNA fragmentation in histiocytic necrotizing lymphadenitis

Higami Y, To K, Ohtani H, Masui K, Iwasaki K, Shiokawa D, Tanuma S, Shimokawa I.

Virchows Arch.   2003年8月

Involvement of DNase gamma in apoptosis associated with myogenic differentiation of C2C12 cells

Shiokawa D, Kobayashi T, Tanuma S.

J Biol Chem.   2002年8月

Isolation and characterization of the DLAD/Dlad genes, which lie head-to-head with the genes for urate oxidase

Shiokawa D, Tanuma SI.

Biochem Biophys Res Commun.   2001年11月

DNA fragmentation in ischemic core and penumbra in focal cerebral ischemia in rats

Yao H, Takasawa R, Fukuda K, Shiokawa D, Sadanaga-Akiyoshi F, Ibayashi S, Tanuma S, Uchimura H.

Brain Res Mol Brain Res.   2001年7月

Characterization of human DNase I family endonucleases and activation of DNase gamma during apoptosis

Shiokawa D, Tanuma S.

Biochemistry   2001年1月

Characterization of two DNase gamma-specific monoclonal antibodies and the in situ detection of DNase gamma in the nuclei of apoptotic rat thymocytes

Shiokawa D, Tanaka M, Kimura T, Hashizume K, Takasawa R, Ohyama H, Fujita K, Yamada T, Tanuma S.

Biochem Biophys Res Commun.   2000年8月

Cloning of a cDNA encoding a rat DNase II-like acid DNase

Tanuma S, Shiokawa D.

Biochem Biophys Res Commun.   1999年11月

DLAD, a novel mammalian divalent cation-independent endonuclease with homology to DNase II

Shiokawa D, Tanuma S.

Nucleic Acids Res.   1999年10月

Cloning of cDNAs encoding porcine and human DNase II

Shiokawa D, Tanuma S.

Biochem Biophys Res Commun.   1998年6月

Molecular cloning and expression of a cDNA encoding an apoptotic endonuclease DNase gamma

Shiokawa D, Tanuma S.

Biochem J.   1998年6月

cDNA cloning of human DNase gamma: chromosomal localization of its gene and enzymatic properties of recombinant protein

Shiokawa D, Hirai M, Tanuma S.

Apoptosis   1998年3月

Purification, characterization, and amino acid sequencing of DNase gamma from rat spleen

Shiokawa D, Iwamatsu A, Tanuma S.

Arch Biochem Biophys.   1997年10月

Purification and properties of DNase gamma from apoptotic rat thymocytes

Shiokawa D, Ohyama H, Yamada T, Tanuma S.

Biochem J.   1997年9月

Inhibitors of poly(ADP-ribose) polymerase suppress nuclear fragmentation and apoptotic-body formation during apoptosis in HL-60 cells

Shiokawa D, Maruta H, Tanuma S.

FEBS Lett.   1997年8月

Occurrence of DNase gamma-like apoptotic endonucleases in hematopoietic cells in Xenopus laevis and their relation to metamorphosis

Nishikawa A, Shiokawa D, Umemori K, Hayashi H, Tanuma S.

Biochem Biophys Res Commun.   1997年2月

An endonuclease responsible for apoptosis

Tanuma S, Shiokawa D.

Prog Mol Subcell Biol.   1996年

Identification of an endonuclease responsible for apoptosis in rat thymocytes

Shiokawa D, Ohyama H, Yamada T, Takahashi K, Tanuma S.

Eur J Biochem.   1994年11月

Multiple forms of nuclear deoxyribonuclease in rat thymocytes

Tanuma S, Shiokawa D.

Biochem Biophys Res Commun.   1994年9月

Sodium benzylideneascorbate induces apoptosis in HIV-replicating U1 cells

Aoki K, Nakashima H, Hattori T, Shiokawa D, Ni-imi E, Tanimoto Y, Maruta H, Uchiumi F, Kochi M, Yamamoto N, et al.

FEBS Lett.   1994年8月

Induction of DNA fragmentation in human myelogenous leukemic cell lines by sodium 5,6-benzylidene-L-ascorbate and its related compounds

Kuribayashi N, Sakagami H, Sakagami T, Niimi E, Shiokawa D, Ikekita M, Takeda M, Tanuma S.

Anticancer Res.   1994年5月

Benzylideneascorbate induces apoptosis in L929 tumor cells

Tanuma S, Shiokawa D, Tanimoto Y, Ikekita M, Sakagami H, Takeda M, Fukuda S, Kochi M.

Biochem Biophys Res Commun.   1993年6月